Application Note: The sterility of the ControLyo™ process: reducing freeze dried product batch time without compromise to system integrity
Controlled nucleation is the most significant new development in freeze drying in quite some time.
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Whitepapers & App Notes
Whitepaper: Feasibility of a Rapid Microbiological Method for filterable raw materials
The Milliflex® Quantum system (Merck Millipore) is a rapid method for the quantitative detection of contaminants in filterable samples...
Application Note: Are you seeing the whole picture with Raman?
Raman spectroscopy offers a rapid, convenient method for positive identification of pharmaceutical products and their raw materials – on the manufacturing floor, in inventory, and at the shipping dock.
Application note: Clean room dehumidification ensures reliable test results
Scandinavian Micro Biodevices (SMB), in Denmark, develops, produces and markets ‘point-of-care’ diagnostic systems for the veterinary market. In order to maintain a very low level of humidity in the clean room, a desiccant dehumidifier is required.
Application Note: Morphological changes in drug compounds under the microscope
Heated crystalline pharmaceutical compounds undergo morphological changes that can be observed under a microscope. With hot-stage microscopy changes in melting points and ranges or crystallisation can be visualised for research and QC purposes in order to influence drug stability or effectiveness...
Application note: In-line PAT solutions for understanding and controlling fluidised bed granulation (FBG) processes
Determining CPP’s in DoE using Eyecon particle characteriser and Multieye Multipoint NIR.
Application Note: Multiparameter profiling of a Structure Activity Relationship (SAR) library for immunological activity in human PBMCs
We describe a no-wash, high throughput screen that provides a multiparametric activity profile for a structure activity relationship (SAR) library derived from immunomodulatory compounds...
Application Note: Instrumental method for quantitation of colour in drug solutions
Measurement and validation of the European Pharmacopoeia (EP) Colour scale.
Application Note: Raman spectroscopy of pharmaceutical ingredients under humidity controlled atmosphere
Monitoring the stability of the API under high humidity is critical to verify that the polymorphic active form remains intact. Being very chemically selective to subtle changes such as polymorphic forms, Raman spectroscopy is used to monitor and understand the stability of ingredients...
Application Note: Rocking Motion cultivation
The BIOSTAT® Rocking Motion (RM) bioreactor system ensures optimal process control and cell growth for all single-use cell culture applications.
Application Note: MALDI-ToF Mass Spectrometry – A valid alternative for microbial identification
MALDI-ToF mass spectrometry, a phenotypical RMM for microbial identification, is a unique, highly accurate alternative method that facilitates cost-effective, precise and rapid data acquisition.
Application note: Enhancing reaction understanding with online NMR reaction monitoring – application to chemical route development
11 January 2016 | By Anna L. Dunn, Analytical Research and Development, Pfizer, Department of Chemistry, University of Wisconsin / Anna Codina, Bruker UK Limited / David A. Foley and Mark T. Zell, Analytical Research and Development, Pfizer
In this work, we demonstrate the complementarity of NMR and infrared (IR) spectroscopy and show the use of NMR to improve the understanding and robustness of the synthesis of an active pharmaceutical ingredient (API) precursor...
Application Note: Direct measurement of challenging target-ligand interactions
GE Healthcare’s most sensitive SPR-based sensor enables accurate interaction analysis of LMW fragments binding to difficult targets.
Application Note: A phenotypic assay for metastasis
BioTek demonstrate a method for the generation of 3D spheroidal structures using a co-culture of a human breast cancer cell line and human fibroblasts embedded in an invasion matrix containing CXCL12 as chemoattractant...
Whitepaper: Enhanced Raman reflection spectroscopy for process analytical technology
This note describes the use of enhanced Raman reflection spectroscopy to accomplish analysis on multi-layered samples similar to many pharmaceutical tablets...
