Biochemical Assay Development Using Novel MALDI High-Throughput Screening System
This whitepaper focuses on developing biochemical assays where substrate and product are small molecules using a novel MALDI-HTS system...
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Whitepapers & App Notes
Application Note: Facilitating filtration of small volumes: HPLC and UHPLC sample prep
Filtrating small volumes of fluid (< 2 mL) can be difficult due to the volume remaining inside the filter after use, so Pall Laboratory have developed 13 mm syringe filters with mini spike outlets for filtration of small volume samples...
Application Note: Method suitability in microbiology: understanding complex cGMP guidelines
Particularly in the pharmaceutical industry, microbiological method development and, specifically, method suitability is often overlooked or left until the end of a project. However, it is important to give both method suitability and development due consideration as it can be a complicated process involving wide specifications, vague parameters and the…
Whitepaper: SWILE pick & decision dispense
Chemspeed's SWILE technology is the first fully automated true one-to-one gravimetric "pick & decision dispense" of compounds...
Whitepaper: Raman Spectroscopy for Polymer Analysis
Find out how recent advances in technology have made Raman spectroscopy better and more affordable for polymer analysis than traditional IR spectroscopy...
Poster note: Fully automated structure verification of organic compounds by combining high resolution accurate MS with NMR data analysis
Here we describe a new approach which automates structure verification for (synthetic) chemists...
Whitepaper: Bioanalytical support in the development of biologics
In this publication Imperacer® case studies demonstrate the advantage of broad assay range combined with excellent sensitivity for several Biologics on their way from R&D to clinics...
Whitepaper: Simultaneous in situ real-time monitoring of a bioprocess
In mammalian-cell-based bioprocesses the most common critical process parameters (CPPs) include physical parameters (temperature, pressure, dissolved oxygen [DO] levels) as well as chemical properties (pH, concentrations of both substrates and byproducts) and biochemical properties (cell number and viability, cell physiology).
Whitepaper: Monitoring a pharmaceutical crystal transformation in situ
Many organic compounds can crystallize in several different forms called polymorphs. Biologically active polymorphs have different solubility and stability and, hence, different bioavailability. The effectiveness of a drug compound depends critically on its particular polymorph.
Whitepaper: Is it essential to sequence the entire 16S rRNA gene for bacterial identification?
The biopharmaceutical industry, especially manufacturing facilities, needs to implement bacterial identification to avoid the occurrence of a problematic microorganism in the final product that could be harmful for the end user and detrimental to a company’s finances and reputation.
Application note: Attaining high transient titers in CHO cells
Case study involving the use of the ExpiCHO™ mammalian transient expression system...
Application Note: In-line Raman spectroscopy for content uniformity
Raman monitoring of blended granule uniformity prior to tablet press...
Application Note: Minding your caps and tails – considerations for functional mRNA synthesis
This article discusses options for selection of reagents and the extent to which they influence synthesised mRNA functionality...
Application Note: MicroNIR PAT for blend monitoring
The aim of Quality by Design (QbD) is to build quality into a product and process from the outset. The pharmaceutical and related industries utilise powder blending operations to make solid dose drugs, yet the phenomena of powder mixing is the least understood of all sciences.
Application note: Purification of nanoparticles by Hollow Fibre Diafiltration
Hollow Fibre Diafiltration is rapid alternative to traditional methods of nanoparticle purification like ultracentrifugation.
