Whitepaper: SWILE pick & decision dispense
The SWILE technology is the first fully automated true one-to-one gravimetric "pick & decision dispense" of compounds...
List view / Grid view
Whitepapers & App Notes
Whitepaper: Regulatory compliance in pharma – software requirements and solutions
In this whitepaper, Metrohm discuss the standardisation organisations put forward for analytical instruments requirements with a focus on software...
Application note: Raman Imaging: A powerful tool for the label-free characterisation of single cells and bacteria
With confocal Raman imaging the molecules of a sample can be chemically identified and their distribution can be imaged three-dimensionally...
Whitepaper: Raman-Based Nutrient Control in Bioprocessing Optimises Viable Cell Density and Protein Glycation
Production of protein therapeutics by mammalian cells is the most widely used bioprocess because of its ability to properly produce and fold a recombinant protein...
Application note: Quantitative Analysis of Immunosuppressant Drugs in Serum Using a QSight 110 Triple Quadrupole Mass Spectrometer
This application note describes a sensitive, fast and accurate LC/MS/MS quantitation method utilising a QSight™ 110 Triple Quadrupole Mass Spectrometer for the simultaneous analysis of the immunosuppressant drugs tacrolimus, sirolimus and cyclosporine A in serum, using everolimus as an internal standard...
Application note: Advancing diagnostics and treatment with Raman imaging
With confocal Raman imaging the molecules of a sample can be chemically identified and their distribution can be imaged three-dimensionally...
Whitepaper: Development of an Efficient Manufacturing Process for Adenovirus
Large-scale downstream processing of viruses for clinical applications poses challenges different from those for many other biotherapeutics. These challenges mostly arise from the size and complexity of the virus...
Whitepaper: Raman-Based Endpoint Detection of a Heterogeneous Etherification Reaction
Raman spectroscopy has been successfully integrated in laboratory, pilot, process development and GMP manufacturing environments. Find out how it was used at the pilot scale to detect the endpoint of a heterogeneous etherification reaction...
Application note: Raman spectroscopy to study the distribution of compounds in a pharmaceutical drug product
In this application note, HORIBA discuss using raman spectroscopy to study the distribution of compounds in pharmaceutical drug products...
Poster: Accelerate antibody drug development with subdomain-specific affinity ligands
Scientists from Thermo Fisher Scientific discuss how the CaptureSelect affinity purification products and analytical tools have been developed for the discovery and manufacturing of therapeutic antibodies, including novel formats such as bi-specific antibodies and Fc-fusion proteins...
Poster: Polyvinyl alcohol in hot melt extrusion to improve the solubility of drugs
This poster evaluates a pharmaceutical grade polyvinyl alcohol (PVA) as the matrix polymer for HME application...
Poster: Microbial survival in compressed gases under fast decompression to normal atmospheric conditions
This scientific poster reviews numerous scientific literature related to microbial survival under a broad range of environmental pressure conditions, and the resilience of microorganisms under variable compression and decompression environments.
Poster: Prevention of dose dumping in PVA-based directly compressed sustained-release matrix tablets
This poster investigates the influence of a directly compressible polyvinyl alcohol (PVA) tablet matrix on the in-vitro drug release that occurs in media of various pH values or alcohol concentrations...
Application note: Rapid identification of illicit drug substances using thermal desorption coupled with a portable toroidal trap GC/MS system
This study describes the injection, separation, and identification of 16 drugs compounds in less than 10 minutes using portable gas chromatograph-toroidal ion trap mass spectrometry (PerkinElmer, Torion® T-9 Portable GC/MS) combined with a coiled-wire-filament (CWF) sampling injector to provide an effective tool for onsite analysis of illicit drugs substances...
Whitepaper: Looking beyond analytical data standardization – the Fourth Paradigm
This paper provides commentary on efforts for analytical data standardization and a vision of the broader considerations and requirements that such an undertaking should include...
