Whitepaper: Solubility: Importance, measurements and applications
The solubility of a compound in organic solvents or water is equally important for screen design and later for process development.
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Whitepapers & App Notes
Flyer: Sterile manufacturing – finished dosage forms
Eurofins CDMO provides a wide range of aseptic processing services for all drug product configurations with flexibility to accommodate a wide range of compounds, primary packaging systems, batch sizes and fill volumes to help develop your Active Pharmaceutical Ingredient or bulk product into Finished Dosage Forms for use in clinical…
Application Note: Simultaneous quantitation/profiling of cell culture medium components using LC-MS/MS
Multi-component methods for the detection of different compound classes, such as vitamins and amino acids, have been established and are widely used to analyse a broad range of samples.
Application Note: Quantitation of intact therapeutic protein in plasma matrix by LC/MS
A complete workflow to quantify intact therapeutic proteins in plasma matrix has been developed, covering three critical components in preclinical sample analysis: target protein enrichment/purification, LC/MS data acquisition and quantitative data analysis.
Whitepaper: Logistic regression model of the endotoxin standard curve and statistical tests
The Monocyte Activation Test (MAT) is used to detect or quantify pyrogenic substances that activate human monocytes.
Application Note: Microbiological considerations in cleanroom validation
Contamination, microbiological or otherwise, is a key safety concern in the development and manufacture of all pharmaceuticals and medical devices.
Whitepaper: A high-quality Raman microscope can be recognised by these five criteria
90 years ago Chandrasekhara Venkata Raman and Kariamanickam Srinivasa Krishnan first documented "A New Type of Secondary Radiation," which then became known as the Raman Effect [1, 2]. Raman spectroscopy is based on this effect and is used for qualitative and quantitative analysis of the chemical components and molecules of…
Application Note: The future of water is clear
Taking advantage of technology developed in recent years, MECO announces smartANALYTICS™ as a means of connecting its water purification machines and systems with big data analytics and in-house expertise.
Application Note: Focus on the fundamentals
Fundamentals. The drab cousins of the headline grabbers like AI or Pharma 4.0. But focusing on them can be the investment that offers the most long-term rewards for companies in terms of risk mitigation, cost reduction and improved overall agility. In pharmaceutical packaging and labelling, the key fundamental is the…
Application Note: Verification of three different Opadry whites using a handheld Raman analyser
Pharmaceutical companies that manufacture tablets, capsules, and other solid dosage forms use film coatings on their products to differentiate appearance and to improve palatability by masking unpleasant tastes or odors.
Application Note: Biologic drug identification at fill and finish
The rapid increase in demand for biopharmaceuticals presents manufacturers with unique challenges to ensure quality and regulatory compliance while maintaining supply and production capacity.
Application Note: Quality manufacturing solution – interfacing with third-party systems
Most organisations that are looking to implement a new LIMS or replace an aging one have a significant investment in a number of information systems.
Whitepaper: Are you facing a complexity crisis?
I spend a lot of time in bland hotels and rarely remember any of them… except one. This particular hotel will, forever, remain etched on my mind because of the complexity of its toilets.
Application Note: Transforming your bioanalysis operations
Many bioanalytical labs work with a crowded and siloed set of systems and processes. From part electronic to part paper-based workflows, to standalone point-solutions, the result is a lack of insight into data and slower reporting and results handling.
Whitepaper: Characterising antibody-drug conjugates using micro pillar array columns combined with mass spectrometry (μPAC™-MS)
The use of micro pillar array columns (μPAC™) for characterising antibody-drug conjugates is presented. Kadcyla® (ado-trastuzumab emtansine) and, for comparison, Herceptin® (trastuzumab) tryptic digests were analysed on a 200 cm μPAC™ C18 column and peaks eluting were detected by ultraviolet (UV) spectroscopy and high-resolution mass spectrometry (MS).
