Article: Fast HPLC using fused-core particle technology for rapid screening of pharmaceutical compounds

HPLC is critical to the discovery, development and eventual commercialization of pharmaceutical products. HPLC is the benchmark analytical method in the pharmaceutical industry due to its ability to score such high marks in analytical validation characteristics; including accuracy, precision, limit of detection, specificity, linearity and range, and ruggedness.

No other analytical techniques can consistently score high in all characteristics on compounds and matrices that are of interest to the pharmaceutical industry.

A major benefit of the Fused-Core particle is the small diffusion path. Furthermore, it has been generally accepted that a typical HPLC analysis takes 15 – 30 minutes, with some taking as long as an hour. When multiplied by the number of samples to be analysed either in discovery or product release, the total instrument time required is staggering. This overwhelming amount of instrument time has resulted in a growing number of instruments, around-the-clock analysis, and a push for faster methods.

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