Whitepaper: Solubility: Importance, measurements and applications

The solubility of a compound in organic solvents or water is equally important for screen design and later for process development.

For designing a screen, for instance around cooling crystallization, you need to select solvents that have sufficient solubility and that have a high dependency of solubility on temperature. In addition, a selection of solvents and mixtures that spans the range of possible chemical functionalities will maximise the chances of finding new, interesting and developable solid forms. This white paper covers two dynamic methods for effective and reproducible solubility data generation: the temperature variation and solvent addition methods. These methods can be easily applied by making use of the turbidity probes integrated in the Crystal16 and particle viewer cameras of the Crystalline instruments.