Poster: Polyvinyl alcohol in hot melt extrusion to improve the solubility of drugs
Posted: 4 July 2017 | Merck | No comments yet
This poster evaluates a pharmaceutical grade polyvinyl alcohol (PVA) as the matrix polymer for HME application…
More than 80 % of current pipeline drugs and approximately 40 % for marketed drugs suffer from limited solubility, which can result in low or variable bioavailability of the active pharmaceutical ingredients (APIs). Hot melt extrusion (HME) is a solid dispersion technology whereby the API is dispersed, often down to the molecular level, into a polymer matrix through application of heat and mechanical energy and processes to form an amorphous solid solution. The aim of this study was to evaluate a pharmaceutical grade polyvinyl alcohol (PVA) as the matrix polymer for HME application. Therefore, performance characteristics such as API solubility enhancement, high thermal stability, and the stability of amorphous solid dispersions at high dose were analyzed.
The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada.
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