Application note: Improving solubility: Stabilising the amorphous state
Posted: 26 August 2021 | Technobis Crystallization Systems | No comments yet
With 16 reactors at 1mL, The Crystal16 enables scientists to determine solubility curves, assess dispersion stability and critical solution temperatures.
Some compounds just don’t have the required solubility or dissolution rate and often they are killed in the development process for just these reasons. Amorphous materials are seen as a solution to this problem, because of their high energy state which gives rise to improves dissolution rates and apparent solubility. The Crystal16 offers an invaluable tool to automate the execution of amorphous solid dispersion screening technology to quickly and effectively identify new solid dispersions of compounds.
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Analytical techniques, Biopharmaceuticals, Bioprocessing, Biosimilars, Excipients, Formulation, Ingredients, Lab Automation, Manufacturing, Research & Development (R&D), Spectroscopy