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Raman In-Depth Focus 2017
This In-Depth Focus looks at photobleaching profile of Raman peaks and surface-enhanced Raman spectroscopic sensing of glucose.
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Raman Spectroscopy
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Surface-enhanced Raman spectroscopic sensing of glucose
The small normal Raman cross-section of glucose is a major challenge in its detection by surface enhanced Raman spectroscopy (SERS) for medical applications, such as blood glucose level monitoring of diabetic patients and evaluation of patients with other medical conditions, since glucose is a marker for many human diseases. Here…
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Photobleaching profile of Raman peaks and fluorescence background
Laser-induced fluorescence is the most common source of interfering baseline signal encountered in Raman measurements. It shows itself as a slowly changing background in a spectrum. One of the challenges in the successful use of Raman spectroscopy is to extract Raman signatures from this, orders of magnitude stronger, broadband fluorescence…
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Issue #6 2017 – Digital Version
This issue celebrates European Pharmaceutical Review's 21st birthday through 21 interviews with leading lights from across the pharmaceutical industry...
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Application Note: A new crystallinity gauge: Real-time quantification and monitoring of crystallinity in pharmaceuticals
The measurement and quantification of crystallinity in pharmaceuticals is of vital importance, as this has a direct influence on the solubility and stability of the final drug product, affecting both efficacy and expiration...
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Application Note: Raman imaging in medical diagnosis and treatment
Confocal Raman imaging is a non-destructive microscopy technique that can identify the molecules in a sample and visualise their distribution in three dimensions...
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Application note: Raman Hyperspectral Imaging: an essential tool in the pharmaceutical field
Resulting from the combination of Raman spectroscopy and optical microscopy, Raman hyperspectral imaging has proven to be an indispensable tool in the pharmaceutical field. This article will broach a number of Raman hyperspectral imaging applications that were developed in our laboratory, to demonstrate the significance of the technique...
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Application note: Representative sampling in process Raman spectroscopy
Raman spectroscopy is an analysis technique that provides a “molecular fingerprint” of the sample, enabling analysis of chemical composition and molecular structure without sample preparation..
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Application note: Raman Imaging: A powerful tool for the label-free characterisation of single cells and bacteria
With confocal Raman imaging the molecules of a sample can be chemically identified and their distribution can be imaged three-dimensionally...
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Whitepaper: Raman-Based Nutrient Control in Bioprocessing Optimises Viable Cell Density and Protein Glycation
Production of protein therapeutics by mammalian cells is the most widely used bioprocess because of its ability to properly produce and fold a recombinant protein...
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Biochemical fingerprints reveal diabetes progression
Researchers have described a new method to study biochemical changes that occur in the pancreas during the development of diabetes...
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Application note: Advancing diagnostics and treatment with Raman imaging
With confocal Raman imaging the molecules of a sample can be chemically identified and their distribution can be imaged three-dimensionally...
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Lasers used to detect risk of heart attack and stroke
Patients at risk of heart attacks and strokes may be spotted earlier thanks to a diagnosis tool that uses near-infrared light...
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Issue #4 2017 – Digital Version
In this issue: Miniaturisation of freeze drying equipment, driving excellence in premises and equipment management, a guide to ingredients, and much more...
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Whitepaper: Raman-Based Endpoint Detection of a Heterogeneous Etherification Reaction
Raman spectroscopy has been successfully integrated in laboratory, pilot, process development and GMP manufacturing environments. Find out how it was used at the pilot scale to detect the endpoint of a heterogeneous etherification reaction...
