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Major step towards Candida auris vaccine developed
Researchers have detailed recent breakthrough experiments that successfully immunised mice against the Candida auris infection.
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Proteins
whitepaper
Whitepaper: Impact of the Claristep® Filtration System on recovery and adsorption of various therapeutic proteins at low sample volumes
Comparison of the Sartorius Claristep Filtration System with standard sample preparation using syringe filters.
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Capsosomes: the revolutionary enzyme carriers
Nature can offer inspiration for the synthesis of more effective drug delivery platforms. In this article, Marc Baiget Francesch discusses the potential of capsosomes as a novel, biocompatible, drug delivery system.
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Expert View: Eshmuno® CP-FT resin – developed for the flow-through removal of aggregates using frontal chromatography
Eshmuno® CP-FT cation exchange resin is specifically designed to provide efficient removal of monoclonal antibody (mAb) aggregates in the flow-through frontal chromatography mode of operation enabling loading capacities 10-times higher than traditional bind/elute CEX chromatography. It facilitates greater manufacturing flexibility and process intensification while reducing the overall cost for the…
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Bioprocessing & Bioproduction In-Depth Focus 2019
The process of manufacturing a biotherapeutic drug entails numerous quality control measures to ensure safety and efficacy. The articles in this in-depth focus discuss higher order structure analysis and host cell protein contamination issues.
news
Proteomics research advanced by use of AI
Researchers succeed in using machine learning to make the mass analysis of proteins faster and almost error-free.
news
New drug for Huntington lowers levels of disease-causing protein
A new drug for Huntington disease is found to be safe and lowers levels of the abnormal protein that causes the debilitating disease in patients.
webinar
Don’t let difficult substances control your cleaning validation
18 April 2019 | By SUEZ
TOC analysis is a widely adopted method for detecting residual product or cleaning agents on manufacturing equipment. Compared to specific methods such as HPLC, TOC can provide better process understanding and efficiency for cleaning validation (CV), verification and continuous monitoring...
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Identification of peptides and proteins in suspected illegal medicinal products using MALDI-TOF-MS
Matrix-assisted laser desorption/ionisation (MALDI) time-of-flight (TOF) mass spectrometry (MS) has proven to be an excellent technique for identification of illegally distributed peptides and proteins for human use. The identification of proteins is mainly based on peptide mass fingerprinting (PMF) – ie, the bottom-up approach – while the small proteins and…
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Protein map using MS-based analysis shared in open database
Study using mass spectrometry-based analysis provides a greater understanding of the cell and a comprehensive map of cell proteins...
whitepaper
Application Note: Quantitation of intact therapeutic protein in plasma matrix by LC/MS
A complete workflow to quantify intact therapeutic proteins in plasma matrix has been developed, covering three critical components in preclinical sample analysis: target protein enrichment/purification, LC/MS data acquisition and quantitative data analysis.
whitepaper
Application Note: Biologic drug identification at fill and finish
The rapid increase in demand for biopharmaceuticals presents manufacturers with unique challenges to ensure quality and regulatory compliance while maintaining supply and production capacity.
news
Diabetes drugs aid macrophages to control inflammation
Dr Lazar’s team identified that TZDs, while working for PPAR gamma, promoted the metabolism of glutamine, an amino acid...
news
Shimadzu partners with Protein Metrics to provide advanced solutions for biotherapeutic protein analysis
Shimadzu, one of the world's fastest growing mass spectrometry companies and Protein Metrics Inc., a leading provider of mass spectrometry software for protein characterisation, today announced a co-marketing agreement for the use of Byos™ with Shimadzu Q-TOF technology...
news
New hope for a syphilis vaccine
Researchers have identified exterior proteins on the bacteria that could serve as vaccine targets for syphilis.
