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Process Analytical Technologies (PAT)

microfluidic biochip for identifying proteins

Miniaturisation helps overcome limitations of PAT, say experts

3 November 2021 | By Hannah Balfour (European Pharmaceutical Review)

Researchers review how miniaturised process analytical technologies (PAT), microfluidic affinity assays and microchip capillary electrophoresis, enhance bioprocess monitoring and control.

Photo of a glowing red machine vision camera in an advanced industry production line - idea of process analytical technologies (PAT)

news

Machine vision allows real-time monitoring and control of low concentration APIs

29 October 2021 | By Hannah Balfour (European Pharmaceutical Review)

Machine vision-based concentration determination enabled the accurate real-time monitoring and control of continuous powder blending.

White tablets flowing along a stainless steel production line - idea of tableting/pharmaceutical production

news

Using co-processed excipient reduces PAT measurement errors, finds study

29 October 2021 | By Hannah Balfour (European Pharmaceutical Review)

New research shows co-processed excipient is superior to non-co-processed when using near infrared (NIR) process analytical technology (PAT) to monitor direct compression tableting.

article

Continuous biomanufacturing – where are we now?

28 October 2021 | By Hannah Balfour (European Pharmaceutical Review)

The biopharmaceutical industry is driven by the need to increase production and reduce costs, while maintaining product quality – and has increasingly been focused on intensification of processes to accomplish this goal. In this article, European Pharmaceutical Review’s Hannah Balfour summarises the potential benefits of implementing continuous bioprocessing and manufacturing…

article

Principal component analysis of Raman spectra for freeze-drying process monitoring

31 August 2021 | By Lukas Kuerten (CPI Biologics), Rachel Findlay (CPI Formulation)

Optical spectral measurement tools are extremely useful both for in-line measurements in process analytical techniques (PATs) as well as for evaluating the composition of finished substances. Here, CPI’s Lukas Kuerten and Rachel Findlay demonstrate a valuable method for gaining useful information from spectral data.

article

Bioprocessing & Bioproduction In-Depth Focus 2021

26 August 2021 | By European Pharmaceutical Review

Download this in-depth focus to discover why shifting away from traditional bioproduction and drug delivery systems could allow antibodies to reach their full potential and how Raman spectroscopy can give useful insights into your processes.

article

Making the journey to PAT and Pharma 4.0

13 July 2021 | By David Leitham (AspenTech)

Here, David Leitham, senior vice president and general manager at AspenTech, explains how implementing PAT pushes the industry towards Pharma 4.0.

3D illustration of Pills with DNA strands inside - idea of gene therapies

news

New consortium to develop PAT for cell and gene therapies

15 June 2021 | By Hannah Balfour (European Pharmaceutical Review)

The Cell and Gene Therapy Catapult’s new consortium aims to accelerate therapeutic development by developing process analytical technologies (PAT) for cell and gene therapy manufacturing.

video

Discussing developments in RMM with Dr Tim Sandle, Bio Products Laboratory

23 April 2021 | By Hannah Balfour (European Pharmaceutical Review)

In this video, Dr Tim Sandle explains how COVID-19 has impacted the application of rapid microbial methods (RMM) and much more...

webinar

Implementing Pharma 4.0 on water systems – FAQ for increasing efficiency with TOC and conductivity

5 February 2021 | By SUEZ – Water Technologies & Solutions

In this on-demand webinar you will learn from two experts with deep expertise in online monitoring, UPW, RTT, TOC, conductivity, cleaning validation and Pharma 4.0.

article

Expert view: Realising real-time TOC testing and Pharma 4.0 improvements in pharmaceutical grade water systems

25 August 2020 | By SUEZ

This expert view from SUEZ discusses how total organic carbon (TOC) and conductivity monitoring are crucial aspects of purified water system quality and control.

webinar

A ground-breaking BET platform for compliant, simplified endotoxin testing: Sievers Eclipse

20 August 2020 | By SUEZ

The new Sievers Eclipse Bacterial Endotoxins Testing (BET) Platform combines ground-breaking technology and ease-of-use to automate endotoxin assay setup without altering reaction biochemistry or compliance. Watch our on-demand webinar to learn more.

webinar

Cleaning validation – a beginner’s guide to increasing efficiency with TOC

19 February 2020 | By SUEZ

Watch our on-demand webinar which will guide you through efficiency gains with TOC for cleaning validation. We call it a ‘beginner’s guide’, but this webinar will benefit long-time TOC users as well as those new to using TOC for cleaning validation.

webinar

A 360 overview of data integrity in life sciences

7 February 2020 | By OSIsoft

Trustworthiness in data is critical for operations within the pharmaceutical and life sciences industries, whether it is for compliance, operational excellence, reporting or development. Hear the latest findings from OSIsoft’s research in our on-demand webinar.

article

Exploring Raman: a non‐invasive analytical approach

20 December 2019 | By Nikki Withers (European Pharmaceutical Review)

Since it was discovered in the 1920s, Raman spectroscopy has been used in pharmaceutical research as a non‐invasive way to provide chemical and structural information in situ, without any staining or complicated sample preparation. Nikki Withers spoke to Professor Kishan Dholakia to hear more about its use in industry and…

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Process Analytical Technologies (PAT)