article
Expert view: Utility of 3D Raman imaging for pharmaceutical studies
Raman microscopy is well suited to pharmaceutical studies, including the analysis of drug delivery systems and their performance.
List view / Grid view
Polymorphs
article
Applying simple PAT tools to crystallisation in process chemistry
Crystallisation is a common step in the synthesis of organic compounds used to isolate and purify the desired product. As the importance of crystallisation has increased and chemists improve the processes involved, process analytical technology (PAT) tools can be used to design, analyse, and control them. This article considers the…
news
How the implementation of Exalt™ for evaporative crystallisation studies improves stability and controlled delivery in drug development.
12 July 2016 | By Biopharma Group
Polymorph screening is an important stage of drug development. The aim is to identify the different crystalline structures or polymorphs that a drug may appropriate...
news
New technique for fast low-level polymorph API quantification using non-destructive transmission Raman spectroscopy
27 May 2016 | By Cobalt Light Systems
A new technique for measuring low-levels of crystalline polymorphic materials offers many advantages over industry standard techniques....
whitepaper
Whitepaper: Monitoring a pharmaceutical crystal transformation in situ
Many organic compounds can crystallize in several different forms called polymorphs. Biologically active polymorphs have different solubility and stability and, hence, different bioavailability. The effectiveness of a drug compound depends critically on its particular polymorph.
article
Issue #5 2015 – Digital edition
In Issue #5 2015: Counterfeit Drugs, Regulatory Insight, Raman In-Depth Focus, PAT Series, Polymorphs, RMM In-Depth Focus, Particle Sizing, Freeze Drying, and much more...
article
Improving solubility with promiscuous multi-component drug crystals
22 October 2015 | By Masataka Ito, Kiyohiko Sugano and Katsuhide Terada Faculty of Pharmaceutical Sciences, Toho University
The physicochemical properties of active pharmaceutical ingredients (APIs) are critical to the success of drug development. Most of the APIs in oral solid dosage forms are contained as drug crystals.
article
Issue #3 2014 – Digital edition
In Issue #3 2014: Pharmaceutical freeze-drying, Self-amplifying mRNA vaccines, Polymorph myths, Microbiology focus, NMR for isotope profiling, Manufacturing with QbD 2.0, Single-cell mRNA-Sequencing, qPCR focus, Powder Flow...
article
Polymorphism – Polymorph myths and misperceptions
The past quarter of a century has seen an enormous increase in the number of papers on the behaviour of the organic solid state, particularly those concerning pharmaceutical polymorphs and solvates. High profile patent cases (ranitidine hydrochloride, paroxetine hydrochloride) combined with product polymorph issues (ritonavir), all of which have carried…
