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Models

Machine learning can predict outcomes for inkjet printed pharmaceuticals

23 May 2023 | By Catherine Eckford (European Pharmaceutical Review)

A paper has shown how machine learning (ML) models predicted the inkjet printing printability of drug formulations with high accuracy.

article

Virtual reality training in pharma: just a headset away?

14 February 2023 | By Dr Blanka Szulc (University of Kent), Dr Stephen Hilton (UCL School of Pharmacy)

Here, Virtual Reality experts UCL’s Steve Hilton and University of Kent’s Blanka Szulc reflect on key developments in the use of virtual reality in an academic setting and its outlook for the future.

news

First virtual clinical trial examines two promising Alzheimer’s drugs

4 November 2022 | By Catherine Eckford (European Pharmaceutical Review)

A first-of-its-kind simulated clinical trial has modelled long-term health outcomes for two key Alzheimer’s drugs to determine optimal treatments.

abstract three-dimensional (3D) big data visualisation

news

Could process data offer a different approach for predicting quality?

7 June 2022 | By Hannah Balfour (European Pharmaceutical Review)

A data collection study provides a product quality dataset that could form the basis of advanced analytical models to predict final product quality.

Concept of airflow - abstract wavy particles on a purple to pink gradient background

news

CFD airflow stimulations can help enhance cleanroom contamination control, finds study

8 April 2022 | By Hannah Balfour (European Pharmaceutical Review)

Researchers used computational fluid dynamics (CFD) simulations to assess their cleanroom airflow and suggest improvements that would reduce contamination levels.

3D rendering of bispecific monoclonal antibody molecules

news

GCD enables product traceability and batch definition in continuous biomanufacturing

12 November 2021 | By Hannah Balfour (European Pharmaceutical Review)

Research shows using the greatest common divisor (GCD) to define batches in continuous biomanufacturing enhances process control and raw material traceability.

white tablets on a pharmaceutical production line - idea of tablet manufacturing

news

Model accurately predicts cyclodextrin formulation stability

26 October 2021 | By Hannah Balfour (European Pharmaceutical Review)

The model determines cyclodextrin complex stability constants as a function of pH and temperature, helping to optimise formulations using cyclodextrin.

illustration of an open capsule with round particles coming out - idea of pharmaceutical excipients/ingredients

news

Excipient knowledgebase to optimise the formulation and dosing of drugs

21 October 2021 | By Hannah Balfour (European Pharmaceutical Review)

Researchers have compiled a repository of clinical and in vitro data for excipients to enable their potential to interact with drugs to be modelled.

world map surrounded by COVID-19 particles

news

Herd immunity is an impractical COVID-19 mitigation strategy, says study

23 September 2020 | By Hannah Balfour (European Pharmaceutical Review)

Researchers who designed a transmission model for COVID-19 demonstrated that attempting to establish herd immunity against COVID-19 would be too challenging.

news

Gattefossé North America announces the recipient of the 2018 award for excellence

30 October 2018 | By Gattefossé

The Gattefossé North America award for excellence in research and development with lipid-based excipients is an annual prize recognising scientific excellence and significant contributions to the field of lipid-based formulations...

news

Mouse model shows success of senolytic drugs in reversing senescent cell damage

11 July 2018 | By European Pharmaceutical Review

An NIH-funded study has demonstrated that a combination of senolytic drugs can successfully reverse cell senescence in mice; providing potential avenue for future age-related treatment study.

news

Organ-chips model and predict thrombotic side effect caused by anti-CD154 antibody hu5c8

3 May 2018 | By European Pharmaceutical Review

An Emulate, Inc. study has demonstrated that its Blood Vessel-Chip accurately modelled and predicted thrombosis, or clotting of blood, induced by certain monoclonal antibody drugs, specifically anti-CD154 monoclonal antibody (mAb) hu5c8.

news

Researchers use novel methods to determine drug uptake for tumours

14 March 2018 | By European Pharmaceutical Review

Researchers at the Moffitt Cancer Center in Florida have combined single-cell imaging of cancer cells in mice with mathematical modelling to establish which drug characteristics determine its efficacy.

news

3d simulation gives authentic representation of left-hand heart mechanisms

2 March 2018 | By European Pharmaceutical Review

A team of scientists in Italy has developed a 3d model that uniquely presents an holistic demonstration of how the left-hand chambers of the heart interact with blood flow and its component parts. The ultimate aim is better prevention and treatment of cardiac conditions.

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Models