news
New JEOL GC/triple quadrupole mass spectrometer introduced at Pittcon
JEOL introduces new GC/triple quadrupole mass spectrometer with high speed and high sensitivity for trace detection of pesticides, dioxins and regulated chemicals.
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Mass Spectrometry
news
Continuous manufacturing method used to make generic lomustine
The goal is to improve manufacturing flexibility, enhance quality and uniformity, while lowering the costs for patients...
article
Mass Spectrometry In-Depth Focus 2019
In this issue: identification of peptides and proteins in suspected illegal medicinal products using MALDI-TOF-MS, and open data policies in proteomics.
article
Identification of peptides and proteins in suspected illegal medicinal products using MALDI-TOF-MS
Matrix-assisted laser desorption/ionisation (MALDI) time-of-flight (TOF) mass spectrometry (MS) has proven to be an excellent technique for identification of illegally distributed peptides and proteins for human use. The identification of proteins is mainly based on peptide mass fingerprinting (PMF) – ie, the bottom-up approach – while the small proteins and…
whitepaper
Application Note: Sensitive quantitation of the ADC ado-trastuzumab emtansine free cytotoxic drug DM1 in serum using MicroLC-MS
Antibody-drug conjugates (ADC’s) are targeted cancer therapeutics that deliver a cytotoxic agent, the payload, to the tumour.
whitepaper
Application Note: Highly selective bioanalytical quantitation method for analysis of R and S amlodipine enantiomers in human plasma using LC-MS/MS
Amlodipine is an angioselective calcium channel blocker used to treat high blood pressure, chest pain and other conditions caused by coronary artery disease.
whitepaper
Application Note: Simultaneous quantitation/profiling of cell culture medium components using LC-MS/MS
Multi-component methods for the detection of different compound classes, such as vitamins and amino acids, have been established and are widely used to analyse a broad range of samples.
news
Protein map using MS-based analysis shared in open database
Study using mass spectrometry-based analysis provides a greater understanding of the cell and a comprehensive map of cell proteins...
whitepaper
Application Note: Quantitation of intact therapeutic protein in plasma matrix by LC/MS
A complete workflow to quantify intact therapeutic proteins in plasma matrix has been developed, covering three critical components in preclinical sample analysis: target protein enrichment/purification, LC/MS data acquisition and quantitative data analysis.
product
Solution stable trypsin at HPLC 2018
SOLu-Trypsin is an Advanced Proteomics Grade enzyme that is solution stable for mass spectrometry.
product
HPLC Workflow solutions
Instrument agnostic consumables available for an HPLC or LC-MS workflow lab.
whitepaper
Whitepaper: Characterising antibody-drug conjugates using micro pillar array columns combined with mass spectrometry (μPAC™-MS)
The use of micro pillar array columns (μPAC™) for characterising antibody-drug conjugates is presented. Kadcyla® (ado-trastuzumab emtansine) and, for comparison, Herceptin® (trastuzumab) tryptic digests were analysed on a 200 cm μPAC™ C18 column and peaks eluting were detected by ultraviolet (UV) spectroscopy and high-resolution mass spectrometry (MS).
whitepaper
Scientific Poster: How complementary chromatographic methods can support a full analytical picture in pharmaceutical drug development
HPLC is a rapid, accurate and sensitive method for determination of pharmaceutical drugs, degradations and impurity profiling. It is a preferred method for analytical characterisation during drug development.
news
Therapeutic cell manufacture could be controlled by molecular exchanger
The Dynamic Mass Spectrometry Probe uses microfluidic technology to help separate compounds of interest from the salts in less than a minute...
