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LC-MS/MS used to identify novel prostaglandin-based compounds
Nitroproston is a novel prostaglandin-based compound with potential application in obstructive respiratory diseases...
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Mass Spectrometry
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Novel methodology increases resolution in oligodendrocyte proteomics
Brazilian researchers combine mass spectrometry, 2-D liquid chromatography and ion mobility to identify over 10,000 proteins in brain cells possibly involved in schizophrenia.
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Integrated imaging method offers unique insights into staph infection
Researchers at Vanderbilt University Medical Center have used an integrated imaging approach to probe an invasive Staphylococcus aureus (‘staph’) infection in a mouse model, revealing new insights about staph infections that can be broadly applied to other diseases.
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Waters BioResolve RP mAb Polyphenyl Columns, setting a new standard for reversed-phase separations of Monoclonal Antibodies and Antibody Drug Conjugates
Waters Corporation (NYSE:WAT) today introduced BioResolve™ RP mAb Polyphenyl 450 angstrom 2.7 micron solid core Columns intended for the reversed-phase analysis of intact or sub-unit-digested monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) using LC-UV and LC-MS...
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Mass Spectrometry In-Depth Focus 2018
This In-Depth Focus looks at the benefits of mass spectrometry for the characterisation of protein higher order structure and for stability testing.
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Issue #1 2018 – Digital Version
In this issue: DNA microarray for detecting, identifying and determining antimicrobial-resistant bacteria; the advantages of single-use technology and a framework for an implementation strategy; risk management when designing chemical safety assessments for pharmaceutical packaging systems.
whitepaper
Handbook: Evolved gas analysis: collected applications
Mass spectrometry is an extremely sensitive method for the detection and identification of traces of gaseous substances. The technique can quantify atoms or molecules and provide chemical and structural information (functional groups and side chains) on the compounds analysed...
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Blood test detects early stages of Alzheimer’s disease
Scientists have developed and validated a blood test for Alzheimer’s disease, with the potential to massively ramp up the pace of Alzheimer’s disease drug trials...
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Measuring molecular interactions using LiP-mass spectrometric analysis
Researchers have systematically analysed and quantified the interactions of all proteins with metabolites on the level of the whole proteome...
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The future of bioanalysis with microchip chromatography
Much rests on the further development of bioanalytical technologies which allow the highest level of sensitivity on small samples, and robust, high reproducibility across large populations. Johan Devenyns, CEO PharmaFluidics, explains further...
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Rapid testing methods: the cost-effective safety solution
When thinking about the future of the pharmaceutical sector, it can be difficult to pinpoint a specific focus as there are a wide range of challenges that come into consideration across all stages of development and manufacturing. Dr Lynne Murdoch, Business Manager – Microbiology, Wickham Laboratories, considers some key points....
whitepaper
Whitepaper: Dwell Volume and Extra-Column Volume: What are they and how do they impact method transfer
Method transfer or method scaling across different instrument platforms can be affected by both dwell volume and extra-column dispersion...
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Mass spectrometry technique could lead to the rapid identification of fentanyl
Researchers have developed a new drug screening technique that could lead to the rapid and accurate identification of drugs...
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Separations & Purifications In-Depth Focus
In this Separations & Purifications In-Depth Focus: Sample preparation - is it possible to have too much? Discover the value of better quality chemistry; Determination of glucosamine in food supplements by HILIC-ESI-MS; Applying simple PAT tools to crystallisation in process chemistry...
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Determination of glucosamine in food supplements by HILIC-ESI-MS
Glucosamine is sold as a food supplement worldwide, but its production is poorly regulated. A direct and reliable method for the quality control of glucosamine in commercial products is of great importance. This article describes a simple, fast and validated ultra-performance liquid chromatography-quadrupole time of flight (UPLC-QToF) for the determination…
