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Innovation with a purpose at Agilent
David Edwards explains how Agilent spectroscopy systems combine core qualities of robustness and reliability with a spirit of innovation.
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Liquid Chromatography - Mass Spectrometry (LC-MS)
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Separations & Purifications In-Depth Focus 2017
In this Separations & Purifications In-Depth Focus: Experts from Leo Pharma explain how they use an MHC 2D-LC system in their analytical troubleshooting laboratory and how it can be applied to solve key tasks in the lab. Plus, Dave Elder explains how guidance for mutagenic impurities has necessitated control of…
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Issue #3 2017 – Digital version
In Issue #3 2017: In-Depth Focuses covering Raman Spectroscopy, Separations & Purifications, Formulation Development & Delivery; Guide To Testing Services; GMP and mutual recognition; Regulatory Insight; RMMs; Microbiology Series; and much more...
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GC-MS applications in pharmaceutical analysis
Gas chromatography (GC) predates the more commonly utilised high performance liquid chromatography (HPLC). However, GC continues to enjoy some important niche applications in modern pharmaceutical analysis, such as the analysis of residual solvents or volatile organic compounds (VOCs)...
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Mass spectrometry in the development of protein biologics
Biological products, usually referred to as biologics, constitute a significant segment of pharmaceuticals in development. Biologics include therapeutic proteins, antibody drugs, antibody-drug conjugates (ADCs), vaccines, carbohydrates drugs, blood and tissue-derived pharmaceuticals, gene therapies, even live cells and tissues...
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ROMIL launches new interactive website
25 October 2016 | By ROMIL
ROMIL is proud to announce the launch of its new website; an easy-to-use, interactive resource for laboratory professionals requiring high purity solvents, acids, reagents and reference materials. This user-friendly, comprehensive reference site has been redesigned from the ground up and optimised for PCs, tablets and smartphones, allowing straightforward browsing of…
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Application of LCMS in small-molecule drug development
As a technology, mass spectrometry (MS) has evolved to the point where it is used throughout the drug development process. In particular, when MS is coupled with high-performance liquid chromatography (HPLC) it adds an orthogonal detection function for sample analysis and provides unique capabilities for pharmaceutical analysis, such as sensitivity,…
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Increasing Throughput and Sensitivity of LC-MS assays with a focus on MS optimisation and novel LC strategies
13 July 2015 | By Sciex
Simplifying peptide quantification with automated optimisation of MRM transitions and advantages of Micro flow LC to maximise LC-MS performance...
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Issue #2 2015 – Digital edition
In Issue #2 2015: Outsourcing, Drug pricing reforms, Stem Cells in-depth focus, Microbiology series, Environmental monitoring, LC-MS in-depth focus, Manufacturing solutions, PAT series and much more...
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LC-MS In-Depth Focus 2015
In this free-to-view LC-MS in-depth focus, we delve into the world of glycans, and how their natural complexity necessitates sophisticated sequencing techniques, while another article aims to demonstrate the versatility of LC-MS and the ease with which it can be combined with a variety of MS systems, focusing particularly on…
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Pharmaceutical proteomics: a journey from discovery and characterisation of targets to development of high-throughput assays
15 December 2013 | By Joerg Reinders, Institute of Functional Genomics, University of Regensburg
Proteomics has evolved during the last few years from a time-intensive, cost-intensive and hard-to-reproduce technique in basic research to a versatile and reliable tool in various areas of pharmaceutical research. The exploding progress in mass-spectrometry-compatible protein and peptide-separation methods led to the development of new approaches particularly suited for monitoring…
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MS-based methods for detection, quantitation and localisation of pharmaceuticals and metabolites in biological samples
18 December 2012 | By Tyler Greer, Department of Chemistry, University of Wisconsin-Madison and Lingjun Li, Department of Chemistry & School of Pharmacy, University of Wisconsin-Madison
Mass spectrometry is a powerful, multi-faceted technique capable of analysing pharmaceuticals and their metabolites in biological matrices. Although it is more commonly applied to proteins, peptides and lipids, an increasing number of studies use mass spectrometry based techniques to detect, quantitate and localise pharmaceuticals and their metabolites. The availability of…
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Recent developments in the use of LCMS in process pharmaceutical chemistry
28 February 2012 | By Dr. Florence O. McCarthy, Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork
Liquid Chromatography Mass Spectrometry (LCMS) is a powerful technique that has recently undergone exponential growth in its application to pharmaceutical synthesis. This perspective will outline the general principles of LCMS, detail some recent approaches and the benefits to be derived from its use at an early stage of process development.…
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Thermo Fisher Scientific introduces Workflows at AACC 2011
Thermo Fisher Scientific Inc. (NYSE:TMO), the world leader in serving science, today introduced a comprehensive range of clinical research and diagnostic products at the annual conference of the American Association for Clinical Chemistry (AACC). From automated sample handling to innovative sample analysis and storage solutions, ThermoFisher provides an integrated approach…
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Thermo Fisher Scientific announces breakthrough workflow for metabolomics research
Thermo Fisher Scientific Inc., the world leader in serving science, today announced a breakthrough workflow to overcome key analytical and informatics challenges in metabolomics.
