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Novel anti-epileptic drug demonstrates efficacy

9 October 2023 | By Catherine Eckford (European Pharmaceutical Review)

Research reveals that a new, potassium-channel opening drug has shown an ability to reduce seizure frequency by more than half in certain epilepsy patients.

news

CHMP recommends cystic fibrosis treatment Kaftrio is granted marketing authorisation

2 July 2020 | By Hannah Balfour (European Pharmaceutical Review)

The European Medicines Agency's human medicines committee (CHMP) said the treatment would offer a therapeutic option for certain cystic fibrosis phenotypes that are currently untreatable.

old man in a hospital bed on a ventilator surrounded by monitors and doctors wearing PPE

news

Interim analysis indicates Auxora^™ is effective in severe COVID-19 pneumonia patients

4 June 2020 | By Hannah Balfour (European Pharmaceutical Review)

Interim results showed Auxora plus standard of care improved time to recovery and reduced ventilator use in patients compared to standard of care alone.

video

Video: Introducing the new SYNAPT XS High Resolution Mass Spectrometer

25 June 2019 | By Waters

Introduced at ASMS 2019, the new SYNAPT XS provides ultimate flexibility offering greater freedom of analytical choice to support scientific creativity and technical success for any application.

news

Using graphene as a tunable ion filter

27 November 2018 | By European Pharmaceutical Review

NIST researchers have shown how graphene can be modified with pores and used as an ion filter, and could be adapted for use in drug delivery systems...

article

Issue #4 2013 – Digital edition

21 August 2013 | By European Pharmaceutical Review

Read the free digital version of the August / September edition of European Pharmaceutical Review magazine...

article

Chloride ion channels and transporters: from curiosities of nature and source of human disease to drug targets

20 August 2013 | By Jonathan D. Lippiat, School of Biomedical Sciences, University of Leeds

Early in their undergraduate education, the student is introduced to various types of integral membrane protein: receptors, adhesion proteins, ion channels, ion pumps and ion transporters. As they progress through their studies, they find out that discrete gene families and protein structures are responsible for these different protein classes and…

article

Indirect modulation of cardiac ion channels and implications for preclinical safety assessment

19 August 2010 | By Gül Erdemli & Dmitri Mikhailov, Center for Proteomic Chemistry, Novartis Institutes for BioMedical Sciences and Albert M Kim, Translational Medicine, Novartis Institutes for BioMedical Sciences

The preclinical assessment of a small molecule’s liability for QT interval prolongation is an essential part of the drug discovery process. Patch clamp assays for heterologously expressed recombinant cardiac ion channels are widely used in the pharmaceutical industry to evaluate potential drug-channel interactions. These assays are generally acute assessments and…

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