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HPLC

Universal detection in high performance liquid chromatography

3 July 2015 | By David P. Elder, Phil Borman and George Okafo - GlaxoSmithKline

The most commonly used analytical technique for the testing of drug molecules is reversed-phase high performance liquid chromatography (RP-HPLC) with ultraviolet (UV)/visible detection. However, one of the biggest constraints affecting UV/visible detectors is their inability to generate adequate sensitivity for analytes lacking a suitable UV chromophore.

news

New high purity grade of solvents for UHPLC-MS instrumentation

29 June 2015 | By Thermo Fisher Scientific

New, exceptionally pure mobile phase solvents for ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS) instruments have been designed to reduce background signal and minimize chromatographic interferences, facilitating accurate, sensitive and rapid trace analysis.

article

LC-MS In-Depth Focus 2015

20 April 2015 | By European Pharmaceutical Review

In this free-to-view LC-MS in-depth focus, we delve into the world of glycans, and how their natural complexity necessitates sophisticated sequencing techniques, while another article aims to demonstrate the versatility of LC-MS and the ease with which it can be combined with a variety of MS systems, focusing particularly on…

HPLC: On-chip liquid chromatographic separation

article

HPLC: On-chip liquid chromatographic separation

17 April 2015 | By Makoto Tsunoda (University of Tokyo)

High-performance liquid chromatography (HPLC) is a powerful separation technique due to its high accuracy, precision, versatility and robustness. In the development of pharmaceuticals, it is no doubt that LC is a key technology in the quality control of pharmaceuticals and pharmacokinetic studies and in the analysis of complex biological compounds…

whitepaper

App Note: How does the analysis of biomolecules benefit from UHPLC?

22 January 2015 | By Thermo Fisher Scientific

Ultra high performance liquid chromatography (UHPLC) provides improved separation speed, throughput, and sensitivity by employing stationary phase particles of around 2μm or smaller.

article

Can HPLC assay methods really be considered quality critical tests?

5 September 2014 | By David Elder (JPAG member and consultant)

Analytical method specificity is assessed using ICH (International Conference on Harmonisation) Q2 (2005). Although, certain methods are not specific enough for their intended purposes, they may have other advantages. Both titrimetric and UV (Ultra-violet spectroscopy) assays are non-specific, but have superior precision (ca. 0.1-0.5% RSD (Residual Standard Deviation)) compared with…

news

Thermo Fisher Scientific transforms chromatography by reimagining UHPLC

18 July 2014 | By Thermo Fisher Scientific

Thermo Fisher Scientific, the world leader in serving science, today unveiled a new high performance liquid chromatography system designed from the ground up to provide new levels of performance, productivity and usability when used as a standalone system or with the latest mass spectrometers

news

Thermo Fisher Scientific introduces expanded chromatography portfolio

20 June 2011 | By Thermo Fisher Scientific

Thermo Fisher Scientific Inc., the world leader in serving science, today announced it will show its expanded portfolio of market-leading chromatography solutions within the Thermo Scientific and Dionex booths at HPLC 2011, a first since Thermo Fisher acquired Dionex.

news

Thermo Fisher Scientific debuts fastest, more sensitive ion trap mass spectrometer

3 June 2011 | By Thermo Fisher Scientific

Thermo Fisher Scientific Inc., the world leader in serving science, today announced fundamentally redefined ion trap mass spectrometer capabilities with the introduction of its new dual-pressure linear ion trap system, the Thermo Scientific Velos Pro.

news

Thermo Fisher Scientific adds new Atlas CDS software control for Shimadzu Prominence HPLC

21 March 2011 | By Thermo Fisher Scientific

Thermo Fisher Scientific Inc., the world leader in serving science, today announced the availability of a new Thermo Scientific Atlas Chromatography Data System (CDS) instrument control software for the Shimadzu Prominence® and Prominence XR HPLC.

article

Test method validation for cleaning validation samples

19 March 2008 | By Richard Forsyth (Merck)

Testing cleaning validation samples requires a validated method. The extent of validation is dependent upon the type of method employed, the capabilities of the method, the scientific and regulatory needs of the resulting data and the anticipated outcome of the testing. A number of test method options are reviewed for…

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HPLC