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Application of LCMS in small-molecule drug development

24 August 2016 | By , ,

As a technology, mass spectrometry (MS) has evolved to the point where it is used throughout the drug development process. In particular, when MS is coupled with high-performance liquid chromatography (HPLC) it adds an orthogonal detection function for sample analysis and provides unique capabilities for pharmaceutical analysis, such as sensitivity,…

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Easy and quick HPLC analysis of Aflatoxin in milk

15 February 2016 | By

Aflatoxins are naturally occurring mycotoxins that are produced by different species of fungi. In addition to the most toxic aflatoxin B1, a number of other related compounds are occurring in nature. High level exposure to aflatoxins can, for example, produce acute hepatic necrosis especially children, whilst adults have higher tolerances.

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Vitamin D Level Determination in Serum

12 February 2016 | By

Vitamin D3 (cholecalciferol) is essential for the human body. Low levels of vitamin D3 increase the risk of illness from a range of disorders. Babies, young children, pregnant mothers and old people are at a higher risk.

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Wanted: clever minds!

10 September 2015 | By Shimadzu

‘lab4you’ program for young scientists / Laboratory space available for research / Brief abstract for application...

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Revolutionising Raman with the transmission technique

3 July 2015 | By Julien Villaumié and Hilary Jeffreys, Actavis

All regulatory agencies require that manufacturers accurately determine the amount of drug in a medicinal product so that the product can be deemed fit for patients. This forms part of batch release testing performed by Quality Control (QC) laboratories. The drug assay and/or content uniformity of the dosage units is…

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Universal detection in high performance liquid chromatography

3 July 2015 | By David P. Elder, Phil Borman and George Okafo - GlaxoSmithKline

The most commonly used analytical technique for the testing of drug molecules is reversed-phase high performance liquid chromatography (RP-HPLC) with ultraviolet (UV)/visible detection. However, one of the biggest constraints affecting UV/visible detectors is their inability to generate adequate sensitivity for analytes lacking a suitable UV chromophore.