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MHRA issues Medicine Defect Information about Aripiprazole
The regulatory body has issued guidance based on a complaint that stated a precipitate formed in Aripiprazole 1mg/ml oral solution.
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Drug delivery method leads to sustained HIV antibody production in study
Using AAV-based technology to deliver mAbs in a Phase I trial, researchers report that participants successfully developed antibodies against HIV.
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Scorpion-derived proteins deliver steroids to combat arthritis in rats
Researchers have identified a tiny protein in scorpion venom that rapidly accumulates in joint cartilage to deliver arthritis drugs in a pre-clinical study.
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Online pharmacy finds high levels of NDMA in metformin
Tests conducted by an online pharmacy has revealed high levels of NMDA in the diabetes drug metformin, prompting the company to press for a recall.
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Thin film platform to preserve vaccines at room temperature developed
A new vaccine formulation has been created by researchers, which uses a peelable film during drying to preserve the medicine.
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Cryogel: a solid vaccine for liquid tumours
Researchers have developed a solid ‘cryogel’ vaccine that has been successful in combatting acute myeloid leukaemia in mice. How was this new formulation discovered and what potential does it have for cancer patients?
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Collaboration for 3D printing of tablets announced
Two companies have announced their partnership to work on the 3D printing of tablets for use in clinical trials.
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Europe’s no 1 trade fair for the fine and speciality chemicals industry returns to Cologne with a strong line-up
Chemspec Europe, the International Exhibition for Fine and Speciality Chemicals, returns to Cologne for its 35th edition. From 27 – 28 May 2020, renowned manufacturers, suppliers and distributors of fine and speciality chemicals present their latest products, services and research findings to a dedicated audience of industry experts.
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FDA and EMA accept licence applications for multiple sclerosis treatment
The FDA and EMA have accepted licence applications for ofatumumab, a novel B-cell therapy for patients with relapsing forms of multiple sclerosis (RMS).
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Oil and hydrogel mix effective for precise dosing of medicine
Researchers have developed a new mixture of oil and hydrogel that releases drugs in a controlled fashion, preventing overdosing.
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FDA Breakthrough Therapy granted to bladder cancer treatment
FDA Breakthrough Therapy Designation has been granted to PADCEV™ in combination with pembrolizumab in first-line advanced bladder cancer.
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Adding natural extracts to medicine formulation improves hypertension drugs
A study has demonstrated that adding certain natural extracts into hypertension drug formulation aids in supporting cardiovascular function.
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How to optimise production by using the correct tablet tooling
Enhancing the production of pharmaceutical tablets is extremely important in modern manufacturing processes and companies will go to great lengths to ensure production runs efficiently in order to stay competitive. As time and capital implications become drivers within the production of solid dosage forms, investigation into improving production methods is…
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Comparative evaluation of pharmaceutical powder flow using different analytical methodologies
Glidants and lubricants are important additives in the production of solid dosage formulations. This article compares the results of various methods to characterise the flowability of blends, demonstrating the importance of considering the impacts that glidants may have, not only on the flowability of blends, but the physical attributes of…
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Polyelectrolyte multilayering: an emerging class of carriers for therapeutic agents
Polyelectrolyte multilayers (PEMs) are promising drug carriers with potential applications in the delivery of poorly soluble drugs. In this article, Sumayah Abdul-Jabbar and Paul Royall discuss the approaches for PEM construction and drug release and detail several applications of multilayered particles in therapeutics.
