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Formulation, Development & Delivery In-Depth Focus 2018
In this In-Depth Focus; early biotherapeutic lead optimisation for more efficient drug discovery and development, and turning promising compounds into drug candidates.
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Drug Discovery
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Dimethandrolone undecanoate shows promise as a male birth control pill
A new birth control pill for men appears to be safe when used daily for a month, with hormone responses consistent with effective contraception...
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MLE490 reduces the number and severity of hot flushes in menopause
A new class of experimental drugs reduces hot flushes in menopausal women by almost three-quarters in just three days...
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Method to predict drug stability could lead to more effective medicines
Researchers have developed a new method to predict the physical stability of drug candidates, which could help with the development of new and more effective medicines for patients...
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Issue #1 2018 – Digital Version
In this issue: DNA microarray for detecting, identifying and determining antimicrobial-resistant bacteria; the advantages of single-use technology and a framework for an implementation strategy; risk management when designing chemical safety assessments for pharmaceutical packaging systems.
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Rational drug design: How far have we come?
From the early use of Hansch parameters and Topliss Trees to today’s computational structure–activity techniques, medicinal chemists have long sought to rationalise drug design to find the quickest and most resource-efficient route to market. But while modern strategies are more reliant on statistical algorithms and vast data libraries, these founding…
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Precision NanoSystems named as one of British Columbia’s fastest growing companies
Precision NanoSystems is one of the fastest growing businesses in British Columbia (BC) according to the recently published Top 100 fastest-growing companies in BC list from business news journal Business in Vancouver (BIV)...
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Aqueous solubility-enhancing excipient technologies: a review of recent developments
At least some degree of solubility in water is necessary for active ingredients in pharmaceutical products to be effective in vivo. However, as efforts to discover and synthesise new active ingredients are pursued by industrial and academic medicinal chemists, achieving sufficient aqueous solubility can often be a significant limitation to…
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Issue #6 2017 – Digital Version
This issue celebrates European Pharmaceutical Review's 21st birthday through 21 interviews with leading lights from across the pharmaceutical industry...
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Whitepaper: Extractables and leachables testing – A risk based approach
Pharmaceutical products are in contact with many external components during both manufacture and usage and small amounts of chemicals may leach from these components with a potential health risk to the patient...
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Smart artificial beta cells could lead to new diabetes treatment
Researchers have designed synthetic beta cells that secrete insulin in response to high blood sugar...
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Albendazole-antibiotic combination shortens therapy for parasitic diseases
Researchers have found a way of reducing the treatment required for lymphatic filariasis and onchocerciasis from several weeks to seven days...
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17th-century style science in the 21st century? The case of the Alzheimer’s disease vaccine
Dante J Marciani, President and CSO of Qantu Therapeutics, reviews the current evidence and controversy in the hunt for a vaccine against Alzheimer's disease and considers the future.
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National Physical Laboratory re-launched to improve access to health innovations
NPL's new approach informed by government priorities, consultancy with industry and the NHS, and a century of expertise, will see it focus on some of the world’s biggest health challenges, from supporting the diagnosis and treatment of cancer and dementia, to reducing attrition rates in drug development, to creating new…
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Romosozumab provides protection against fractures in osteoporosis
A new treatment for osteoporosis provides major improvements in bone density and fractures than the current standard treatment...
