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Artificial DNA can control release of active ingredients from drugs
A team at the Technical University of Munich have made it possible for nano particles to be released in sequence with the use of artificial DNA.
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Higher rifampin doses for TB appear more effective with no greater risks
Higher daily doses of rifampin, a cornerstone of tuberculosis treatment, were shown to kill more TB bacteria in sputum cultures without increasing the adverse effects of treatment, according to a recent randomised controlled trial.
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HRT trial demonstrates improved memory function in adrenal patients
Better timing for cortisol replacement therapies, to more closely replicate the secretion patterns of people with normal levels of the hormone, has shown a significant improvement in patients' cognitive function...
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Oral sirolimus alters the course of DIPNECH syndrome
Sirolimus, which is used to prevent rejection after kidney transplants has been used to treat idiopathic pulmonary neuroendocrine cell hyperplasia...
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Larotrectinib shows promise in paediatric patients with TRK gene mutations
A new cancer drug has proven safe and effective for paediatric patients with a rare tumour gene mutation...
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Taking a standard prostate cancer drug with food boosts impact
By taking Zytiga with a low-fat meal could decrease the daily dose and prevent digestive issues...
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High doses of favipiravir may be effective against Ebola
High doses of favipiravir extended survival in non-human primates infected with Ebola virus, according to a new study....
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Study of childhood asthma cautions against short-term high-dose treatment with steroids
Researchers in the US have found that a common practice among physicians to increase the use of steroids for worsening symptoms of asthma in children may be associated with slowing a child’s rate of growth.
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Packaging In-Depth Focus 2018
This Packaging In-Depth Focus explores the risks around interactions between drugs and their packaging and looks at how smart packaging may help patients take their medication accurately.
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Short-acting asthma relievers linked to infertility
New research indicates that women with asthma who only use short-acting asthma relievers take longer to become pregnant than other women...
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Non-clinical dose formulation considerations
Designing appropriate non-clinical safety studies requires thoughtful, and sometimes experimental, consideration of the delivery methodology for the therapeutic. The choice of formulation affects drug release and absorption and has a direct impact on the pharmacokinetic profile and associated response of the model system. The formulation should be compatible with the…
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Shorter treatment course better for intermediate risk prostate cancer?
New research suggests that treatment with a shorter course of radiation using higher doses over fewer days may be the preferred approach for some men with intermediate-risk prostate cancer.
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FDA approves new dosing for Xarelto to reduce the risk of VTE
The FDA has approved the 10 mg once-daily dose of Xarelto, for reducing the continued risk of recurrent venous thromboembolism...
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Dual antithrombotic therapy cuts bleeding risk
Researchers have found that using just two anti-clotting medicines for atrial fibrillation is safer than using the current standard treatments...
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EU approval for Regeneron and Sanofi’s rheumatoid arthritis drug
The European Commission (EC) has granted marketing authorisation for Regeneron and Sanofi’s Kevzara (sarilumab) for the treatment of rheumatoid arthritis...
