news
Patient dosed with first Lassa fever vaccine to reach human trials
The first trial participant has been given INO-4500 in Ghana - INO-4500 is a DNA vaccine candidate being developed to protect against Lassa fever.
List view / Grid view
DNA
news
UK to revolutionise oligonucleotide medicines manufacturing
Collaborators on Grand Challenge 3 will utilise their combined expertise to transform the oligonucleotide supply chain.
whitepaper
Application note: Synthesis confirmation for nucleic acid medicines – rapid sequence confirmation using a MALDI-TOF mass spectrometer
Medicines that utilise nucleic acids, such as DNA and RNA which control genetic information, are called "nucleic acid medicines".
article
Single-cell analysis techniques: advances enabling early diagnosis of genetic diseases
In this article Pramod Kumar, a Senior Research Analyst (Healthcare) at P&S Intelligence, explores how single-cell analysis techniques are used for both pharmaceutical R&D and clinical, diagnostic applications.
article
Expert view: How robust is your fungal ID strategy?
This expert view from Charles River explores the different methods of fungal identification, allowing you to proactively address issues before they occur and provide information for successful remediation.
article
Anti-cancer drug delivery: peptoid-coated DNA origami
Scientists have designed and synthesised chains of molecules for the purpose of drug delivery with a precise sequence and length to protect DNA nanostructures from degradation under biomedically relevant conditions.
news
DNA nanostructure stabilisation could enable translation into clinical use
Stabilising DNA nanostructures using glutaraldehyde to tether an electrostatic PEGylated oligolysine net to the DNA enabled them to survive degradation in animal models.
article
Viral vectors for gene therapy
The first gene therapy products are appearing commercially and the field is growing rapidly with over 350 clinical trials taking place in H1 of 2019 alone. So why is this area attracting so much attention? Dr Philip Probert and Dr Stuart Jamieson discuss the potential of gene therapy and the…
news
Artificial DNA can control release of active ingredients from drugs
A team at the Technical University of Munich have made it possible for nano particles to be released in sequence with the use of artificial DNA.
whitepaper
Scientific Poster: Development of cGMP-Ready purification process for advenovirus purification
Large-scale downstream processing of viruses for clinical applications poses challenges different from those for many other biotherapeutics...
news
DNA test may detect liver cancer
A group of researchers have completed a phase II study comparing a set of DNA markers to alpha-fetoprotein as a method to test for liver cancer....
news
Talazoparib shows promise for early-stage BRCA+ breast cancer patients
Once-daily oral pill could replace preoperative chemotherapy in patient population if validated in larger trials...
news
Blood test shows potential for early detection of lung cancer
A test that analyses free-floating DNA in the blood may be able to detect early-stage lung cancer...
news
Web tool predicts phenotypes from a DNA sample
An international team of scientists have developed a novel tool to accurately predict eye, hair and skin colour from human biological material...
news
RNA-based therapy cures lung cancer
By turning down the activity of a specific RNA molecule, researchers have cured lung tumours in mice...
