whitepaper
Whitepaper: IC – The all-rounder in pharmaceutical analysis
In this whitepaper, Metrohm discuss ion chromatography and take a look at some pertinent trends and recent advances in its application...
List view / Grid view
Chromatography
webinar
SIFT-MS: A New Tool for Impurity Profiling in Pharmaceutical Products
21 February 2017 | By Syft Technologies
SIFT-MS is a new tool for real-time, selective and economical trace gas and headspace analysis. SIFT-MS uses soft chemical ionisation to quantify volatile compounds, including chromatographically challenging ones such as formaldehyde, formic acid, and ammonia...
article
HPLC In-Depth Focus 2016
In this HPLC In-Depth Focus: Resolving natural compound complexity with multidimensional chromatography; The advantages of temperature elevations in HPLC...
news
Pall Life Sciences launches the Cadence™ BioSMB Process system to enable fully scalable, continuous multi-column chromatography
5 October 2016 | By Pall Life Sciences
Pall Life Sciences is pleased to announce the commercial launch of the Cadence BioSMB Process system single-use flow path, continuous multi-column chromatography system...
news
New version of Clarity Chromatography Software expands portfolio of controlled instruments and introduces new features
2 June 2016 | By DataApex
Clarity version 7.0 has the reorganized installation structure, which allows better access to data and a new robust system of custom units...
news
HPLC Congress 2016- Exploring the boundless analytical techniques
16 September 2015 | By HPLC
Microanalysis which is critical in today’s research is ushered by boundless analytical techniques, the major one being HPLC...
article
Universal detection in high performance liquid chromatography
3 July 2015 | By David P. Elder, Phil Borman and George Okafo - GlaxoSmithKline
The most commonly used analytical technique for the testing of drug molecules is reversed-phase high performance liquid chromatography (RP-HPLC) with ultraviolet (UV)/visible detection. However, one of the biggest constraints affecting UV/visible detectors is their inability to generate adequate sensitivity for analytes lacking a suitable UV chromophore.
article
HPLC: On-chip liquid chromatographic separation
High-performance liquid chromatography (HPLC) is a powerful separation technique due to its high accuracy, precision, versatility and robustness. In the development of pharmaceuticals, it is no doubt that LC is a key technology in the quality control of pharmaceuticals and pharmacokinetic studies and in the analysis of complex biological compounds…
article
Can HPLC assay methods really be considered quality critical tests?
Analytical method specificity is assessed using ICH (International Conference on Harmonisation) Q2 (2005). Although, certain methods are not specific enough for their intended purposes, they may have other advantages. Both titrimetric and UV (Ultra-violet spectroscopy) assays are non-specific, but have superior precision (ca. 0.1-0.5% RSD (Residual Standard Deviation)) compared with…
article
Bio-mimetic chromatography to predict drug distribution in vivo
29 October 2010 | By Klara Valko, Analytical Chemistry, GlaxoSmithKline Medicines Research Centre
A major concern for the pharmaceutical industry is the high attrition rate (>90 per cent) of potential drug molecules failing during late stages of the drug discovery process. This may be due to lack of efficacy in the clinic, unexpected side effects or unfavourable pharmacokinetics. There is a need for…
article
New phases for rapid ion analysis
7 March 2005 | By Dr Brett Paull and Prof. Pavel Nesterenko, Research Scientists, National Centre for Sensor Research, Dublin
Ion chromatography (IC) is currently used throughout chemical and pharmaceutical industries for the quantitative determination of inorganic and organic anions and cations in a variety of matrices from both raw materials to finished products. In most cases, suppressed IC is utilised, particularly for the determination of inorganic anions and this…
