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Antibody-drug conjugates (ADC) represent a rapidly emerging class of biotherapeutic molecules, which harness the specificity of monoclonal antibodies (mAb) to selectively deliver highly potent cytotoxic drugs. Like all biotherapeutics they require significant analytical characterization.
The latest research and developments from Pharma and Biopharma industry experts.
According to a new report, regular infusions of an antibody that blocks the HIV binding site on human immune cells may have suppressed levels of HIV for up to four months in people undergoing a short-term pause in their antiretroviral therapy (ART) regimens.
Eurofins CDMO provides a full suite of drug development services encompassing development of the bioprocesses, formulation screening, analytical development, pre-clinical testing, sterile and non-sterile bio-manufacturing of clinical trial batches and orphan drugs.
The use of micro pillar array columns (μPAC™) for characterising antibody-drug conjugates is presented. Kadcyla® (ado-trastuzumab emtansine) and, for comparison, Herceptin® (trastuzumab) tryptic digests were analysed on a 200 cm μPAC™ C18 column and peaks eluting were detected by ultraviolet (UV) spectroscopy and high-resolution mass spectrometry (MS).
Infliximab, commercially known as Remicade, is a chimeric IgG1 kappa monoclonal antibody (mAb), that targets tumor necrosis factor-alpha (TNF)....
Inhibiting protein kinase C-alpha was shown to be a pivotal step towards restoring the damage done by nephritis...
Tiny drug-filled nanocarriers, termed ‘nano-submarines’, are being developed to boost the targeted treatment of headaches and tumours, without damaging healthy tissue...
Results from a pivotal trial of a new HIV therapy, show that PRO 140 is an effective, long-acting therapeutic for previously treated HIV-1 infected patients...
Scientists developed monoclonal antibody from Ebola survivor...
Two new studies of patients with difficult-to-control asthma show that the eczema drug dupilumab alleviates asthma symptoms and improves patients' ability to breathe better than standard therapies...
An Emulate, Inc. study has demonstrated that its Blood Vessel-Chip accurately modelled and predicted thrombosis, or clotting of blood, induced by certain monoclonal antibody drugs, specifically anti-CD154 monoclonal antibody (mAb) hu5c8.
In this In-Depth Focus; enabling the manufacture of robust biologic drug products, automating biopharmaceutical development, and greater compatibility and ease of use for bioproduction monitoring of monoclonal antibodies.
Medical researchers point to a promising route for designing an effective vaccine for the respiratory syncytial virus...
Waters Corporation (NYSE:WAT) today introduced the Waters® ACQUITY™ Arc™ Bio System, a versatile, iron-free, bio-inert, quaternary liquid chromatograph specifically engineered to enable the efficient transfer and improvement of bioseparation analytical methods regardless of the LC platform on which the original method was developed...
