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Scientific Poster & Whitepaper Gallery 2019
The latest research and developments from Pharma and Biopharma industry experts.
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Antibodies
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Regular infusions of a novel antibody may suppress HIV for four months
According to a new report, regular infusions of an antibody that blocks the HIV binding site on human immune cells may have suppressed levels of HIV for up to four months in people undergoing a short-term pause in their antiretroviral therapy (ART) regimens.
whitepaper
Flyer: Biologicals drug substance and drug product
Eurofins CDMO provides a full suite of drug development services encompassing development of the bioprocesses, formulation screening, analytical development, pre-clinical testing, sterile and non-sterile bio-manufacturing of clinical trial batches and orphan drugs.
whitepaper
Whitepaper: Characterising antibody-drug conjugates using micro pillar array columns combined with mass spectrometry (μPAC™-MS)
The use of micro pillar array columns (μPAC™) for characterising antibody-drug conjugates is presented. Kadcyla® (ado-trastuzumab emtansine) and, for comparison, Herceptin® (trastuzumab) tryptic digests were analysed on a 200 cm μPAC™ C18 column and peaks eluting were detected by ultraviolet (UV) spectroscopy and high-resolution mass spectrometry (MS).
whitepaper
Scientific Poster: Quantitation of monoclonal antibody infliximab in human plasma by LC-MS/MS using Fab-selective limited proteolysis nSMOL technology
Infliximab, commercially known as Remicade, is a chimeric IgG1 kappa monoclonal antibody (mAb), that targets tumor necrosis factor-alpha (TNF)....
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Protein kinase C-alpha inhibitor reverses destructive nephritis
Inhibiting protein kinase C-alpha was shown to be a pivotal step towards restoring the damage done by nephritis...
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‘Nano-submarines’ to help target headaches and tumours
Tiny drug-filled nanocarriers, termed ‘nano-submarines’, are being developed to boost the targeted treatment of headaches and tumours, without damaging healthy tissue...
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Weekly injections shows HIV-1 viral suppression
Results from a pivotal trial of a new HIV therapy, show that PRO 140 is an effective, long-acting therapeutic for previously treated HIV-1 infected patients...
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NIH begins testing Ebola treatment in early-stage trial
Scientists developed monoclonal antibody from Ebola survivor...
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Eczema drug effective against severe asthma
Two new studies of patients with difficult-to-control asthma show that the eczema drug dupilumab alleviates asthma symptoms and improves patients' ability to breathe better than standard therapies...
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Organ-chips model and predict thrombotic side effect caused by anti-CD154 antibody hu5c8
An Emulate, Inc. study has demonstrated that its Blood Vessel-Chip accurately modelled and predicted thrombosis, or clotting of blood, induced by certain monoclonal antibody drugs, specifically anti-CD154 monoclonal antibody (mAb) hu5c8.
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Biopharma Processing & Development In-Depth Focus 2018
In this In-Depth Focus; enabling the manufacture of robust biologic drug products, automating biopharmaceutical development, and greater compatibility and ease of use for bioproduction monitoring of monoclonal antibodies.
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Antigen study provides a new approach to vaccine development for RSV
Medical researchers point to a promising route for designing an effective vaccine for the respiratory syncytial virus...
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Waters New ACQUITY Arc Bio System brings advanced method transfer capabilities to routine bioseparations
Waters Corporation (NYSE:WAT) today introduced the Waters® ACQUITY™ Arc™ Bio System, a versatile, iron-free, bio-inert, quaternary liquid chromatograph specifically engineered to enable the efficient transfer and improvement of bioseparation analytical methods regardless of the LC platform on which the original method was developed...
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Waters BioResolve RP mAb Polyphenyl Columns, setting a new standard for reversed-phase separations of Monoclonal Antibodies and Antibody Drug Conjugates
Waters Corporation (NYSE:WAT) today introduced BioResolve™ RP mAb Polyphenyl 450 angstrom 2.7 micron solid core Columns intended for the reversed-phase analysis of intact or sub-unit-digested monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) using LC-UV and LC-MS...
