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Jean Horbach

 

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Segregation of molecular mechanisms of genotoxicity and carcinogenicity across human, yeast and Salmonella species

Screening assays for in vitro toxicity are the way to…

22 February 2010 | By

Screening assays for in vitro toxicity are the way to reduce the attrition rates in the preclinical development of new drugs. Here a test battery is presented for screening of genotoxic and carcinogenic compounds by means of VitotoxTM, RadarScreen, and four human liver HepG2 cell lines with two different promoters…

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In vitro toxicity screening as pre-selection tool

Drug discovery relies on massive screening of compound libraries with…

19 June 2008 | By

Drug discovery relies on massive screening of compound libraries with in vitro cell-based target assays. These pharmacological screens have been well accepted. For in vitro toxicological screening, this privilege has only been obtained for the Ames, chromosomal aberration and eye irritation tests. At the moment, a number of cellular assays…