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Edward Ainscow

 

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Addressing kinetic applications in High Content Screening

Traditional drug discovery screening assays tend to employ simplistic endpoint…

29 September 2008 | By

Traditional drug discovery screening assays tend to employ simplistic endpoint assays that often monitor the activity of a single target. While these approaches are amenable to high-throughput screening they provide limited information on how candidate drugs influence complex biological systems that exist in vivo. Such limitations are a contributing factor…

article

Statistical techniques for handling high content screening data

One of the chief incentives for the use of high…

21 September 2007 | By Edward Ainscow, Research Scientist, AstraZeneca

One of the chief incentives for the use of high content screening (HCS) approaches is the data rich return one gets from an individual assay. However, conventional methods for hit selection and activity determination are not well suited to handling multi-parametric data. Tools borrowed from the genomics area have been…