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Can mTOR kinase inhibitors beat rapalogues in fighting against cancer?

19 February 2014 | By

The mammalian target of rapamycin (mTOR) has emerged as a promising cancer therapeutic target. Some rapamycin analogues (rapalogues) as mTOR allosteric inhibitors are FDA-approved drugs for treatment of certain types of cancers. However, the modest clinical anticancer activity of rapalogues, which preferentially inhibit mTOR complex 1, in most types of…

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PCR In-Depth Focus 2013

25 October 2013 | By

In this PCR In-Depth Focus: Challenges for qRT-PCR in detecting / quantifying microRNA in vitro and in vivo; Emerging clinical applications of digital PCR; Workshop Preview: Advanced 3d cell based assays, preparation, analysis and troubleshooting...