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Process Analytical Technologies (PAT) in the pharmaceutical industry
European Pharmaceutical Review brings you a comprehensive guide to the current developments and possible future innovations within Process Analytical Technologies...
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AstraZeneca
AstraZeneca plc is an Anglo–Swedish multinational pharmaceutical and biopharmaceutical company.
In 2013, it moved its headquarters to Cambridge, United Kingdom, and concentrated its R&D in three sites: Cambridge, Gaithersburg, Maryland (location of MedImmune) for work on biopharmaceuticals, and Mölndal (near Gothenburg) in Sweden, for research on traditional chemical drugs. In 2015, it was the eighth-largest drug company in the world based on sales revenue.
AstraZeneca has a portfolio of products for major disease areas including cancer, cardiovascular, gastrointestinal, infection, neuroscience, respiratory and inflammation. The company was founded in 1999 through the merger of the Swedish Astra AB and the English Zeneca Group (itself formed by the demerger of the pharmaceutical operations of Imperial Chemical Industries in 1993). It has made numerous corporate acquisitions, including Cambridge Antibody Technology (in 2006), MedImmune (in 2007), Spirogen (in 2013) and Definiens (by MedImmune in 2014).
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EuPAT: an initiative to promote progress in the science underpinning PAT
23 May 2007 | By Staffan Folestad, Senior Principal Scientist, AstraZeneca, Sweden; Peter York, Bradford University, UK, and Rasmus Bro, Copenhagen University, Denmark
A new initiative launch has been announced that aims to promote progress in the science underpinning Process Analytical Technology. The core purpose of the EuPAT meeting is the creation of an open and neutral scientific forum for sharing and discussing new findings in cutting-edge scientific research, development of enabling technologies…
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New opportunities for understanding
23 May 2006 | By Lubomir Gradinarsky, Jonas Johansson, Mike Claybourn, Husheng Yang, Matti U.A. Ahlqvist and Staffan Folestad, Pharmaceutical and Analytical R&D, AstraZeneca R&D Mölndal
By taking advantage of new technology previously developed mainly for radio astronomy, biological investigations and military applications, the emerging field of Terahertz (THz) Spectroscopy is starting to make its way into pharmaceutical analysis. This overview describes the new opportunities with THz Spectroscopy for rapid and non-destructive analysis of pharmaceutical materials…
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Partnering for better science
23 May 2006 | By Hans Hultberg, Head of Global Discovery Alliances, AstraZeneca
There are nearly 12,000 people within the AstraZeneca R&D community who all share a common aim: to bring life-changing medicines to patients as quickly as possible. Our efforts are evident in a rich research history that has delivered new treatments for gastrointestinal, cardiovascular, neurological and respiratory diseases, along with pioneering…
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Biomarkers of efficacy and safety
22 August 2005 | By Dr Graham R Betton, Senior Principal Scientist, Safety Assessment, AstraZeneca Pharmaceuticals
This article reviews the types of biomarkers currently available and approaches to discovering new biomarkers.
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The AstraZeneca ACMF
22 August 2005 | By Dr Dalin Nie, Associate Director, and Deborah S. Hartman, Director, Lead Discovery, AstraZeneca Pharmaceuticals, Wilmington
Compound management is an emerging discipline that represents a core component of the drug discovery process, from early phases involving high throughput screening (HTS) to late-stage lead optimisation screening cascades.
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A powerful tool for drug discovery
20 May 2005 | By Jianwei Liu and Clay W Scott, AstraZeneca Pharmaceuticals, Wilmington, USA
Receptor-ligand binding assays are extremely powerful tools in drug discovery. With advances in technology and methodology, the traditional radioligand filtration assays are being replaced with higher throughput homogeneous assays. Non-radioactive methods have been developed recently that are particularly applicable to early phase drug discovery.
