Study suggests current drug shortages in US will be worsened by COVID-19 pandemic

A new study has highlighted that the US currently has a high level of drug shortages, which is being compounded by the COVID-19 pandemic. 

The researchers also provide recommendations on how clinicians and institutions in the US might address potential scarcities of essential medications during the current public health crisis.

Dr Andrew Shuman and co-authors discuss in their paper how the federal and state governments, as well as health care providers, need to develop ethically sound policies that address already low supplies of certain commonly-used medications, which are dwindling further due to resources needed to combat COVID-19.

“It is critical that these conversations occur now due to current shortages, as well as the necessary lead time to plan for future shortages,” said Dr Shuman, co-chief of the Clinical Ethics Service, Center for Bioethics and Social Sciences in Medicine, University of Michigan Medical School. “Drug shortages have been a national emergency for years and are currently exacerbated due to COVID-19. Issues related to supply chain and anticipated increased intensive care unit (ICU) needs over the course of the pandemic are worsening the problem.”

Dr Yoram Unguru, a physician-ethicist at The Herman and Walter Samuelson Children’s Hospital at Sinai and Johns Hopkins Berman Institute of Bioethics, who is a co-author of the paper, added: “As of today, the American Society of Health-system Pharmacists (ASHP) reports 213 drugs shortages in the US. It is not just patients with COVID-19 who are affected. One example of a current drug with a critically short supply is Erwinia asparaginase, a life-saving chemotherapeutic agent for both children and adults with cancer.”

According to the researchers, among medical specialities severely affected are oncology, critical care and infectious disease.

The authors state that regional communication among hospitals is an important first step – helping determine how local drug supply chains are affected – and that co-ordination and sharing mechanisms are also critical.

They posit that this information sharing would ideally occur via a central repository or clearinghouse. Both the US Food and Drug Administration (FDA) and ASHP also maintain databases of current drug shortages and independent health care companies maintain their own databases that can provide invaluable information.

“Sharing information is an important first step,” the authors say. “The second and more difficult step involves actual sharing of medications among hospitals and health systems.”

The researchers say that there are a number of barriers preventing this, including the need for co-operation among competing health systems, concerns about potential liability and legal regulations that affect the transfer of drugs.

Dr Erin Fox, a co-author who is director of drug information and support services for Utah Health noted: “Tantamount to this effort is facilitating communication between pharmacists – those tasked with maintaining supplies, as well as those embedded within clinical teams – in order to inform the clinical team how supply may impact care delivery… Pandemic-era strategies for conservation of commonly used critical care agents at risk of shortages should be noted, recognising that these shortages are often regional and unpredictable and intensive care protocols and strategies are highly individualised.” 

In the spirit of openness, the authors also recommend that hospitals consider publicly posting information about drug shortages.

Dr Shuman and colleagues called upon stakeholders, from governments to clinicians, to refocus some of their efforts in managing shortages of ventilators during the COVID-19 crisis to develop workflows and rationing criteria for essential medicines. “Even if there are sufficient ventilators, a critical shortage of sedatives, paralytics and/or opioids will obviate the ability to keep patients safely intubated. Data suggest that these shortages have already been associated with inadvertent extubations.”

The authors have also identified hoarding of drugs thought to be potential COVID-19 treatments as a problem.

“Once effective treatments and/or vaccines for COVID-19 are available, prioritising nascent supplies will present a formidable challenge,” they predict. “In the coming days and months, this matter demands global attention. Only with clear lines of communication and a proactive, collaborative approach can we weather this impending storm.”

The study was published in Annals of the American Thoracic Society.