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Issue 6 2008

 

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Detecting microRNA targets or siRNA off-targets using expression data

3 December 2008 | By

Recently, small RNAs such as microRNAs (miRNAs) have been demonstrated to be important regulators in both plants and animals. In animals miRNAs act as translational repressors of target genes through a combination of inhibition of translation and mRNA destabilisation. These molecules have been implicated in a multitude of diseases, including…

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European PROSPECTS for proteomics and systems biology

3 December 2008 | By

In its Research Framework Programme 7 (2007-2013), the European Commission sets the focus in health research on bringing the huge high-throughput data collection efforts of earlier programmes to the systems level. The ultimate goal of systems biology is the integration of various types of experimental data into models that represent…

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The third annual Stem Cells World Congress

3 December 2008 | By

This year’s congress will include the Keynote Speakers Bernard Siegal, Executive Director at the Genetics Policy Institute, Jan Nolta, Director at the Stem Cell Programme in the University of California and Carolyn Compton, Director at the Biorepositories and Biospecimen Research in the National Cancer Institute.

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The original HCA event

3 December 2008 | By

Last year over 400 thought leaders gathered at the Fifth Annual High-Content Analysis meeting at the San Francisco Fairmont Hotel, on 14-17 January, to discuss the latest technologies and applications in high-content analysis. This year over 400 delegates are expected to attend and over sixty speakers will appear.

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Where science, technology and industry come together

3 December 2008 | By

From around the world, a diverse and highly innovative group of academicians, scientists, engineers, post-doctoral associates, graduate students, and business leaders will converge at LabAutomaton2009. The show will be held on 24-28 January 2009, at the Palm Springs Convention Centre, Palm Springs, California.

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Neurotoxicity in preclinical studies

3 December 2008 | By

Neurotoxicology is not a discipline that can expect to be popular in pharmaceutical circles. It is a not unreasonable prejudice amongst people working in drug development that even a suggestion that a candidate drug might be neurotoxic is enough to halt development, or at the least to stimulate a highly…

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Application of DSC and MDSC in the development of freeze dried pharmaceuticals

3 December 2008 | By Jakob Beirowski, Pharmacist and Dr. Henning Gieseler, Assistant Professor, Division of Pharmaceutics, University of Erlangen-Nuremberg

Freeze drying of pharmaceuticals requires an adequate formulation design to prevent low-temperature, freezing and drying stresses. The goal is to achieve a final product with long storage stability and elegant appearance. To meet these specifications the product temperature must be controlled below the critical formulation temperature during the freeze drying…

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Disinfectant validation

3 December 2008 | By

The design, validation and implementation of a documented and approved disinfectant programme must form a key part of any pharmaceutical production area qualification. There is significant regulatory interest in this area as it forms a fundamental part of any production facility maintenance schedule. European pharmaceutical companies are required to implement…

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A practical approach to microbial testing to support non-sterile product stability

3 December 2008 | By

During stability, product testing is performed to ensure the product will continue to meet specified criteria of quality and strength through its expiration or shelf-life at the temperature and humidity required by specific markets. This article will not address the other stability requirement of continued efficacy during consumer use which…

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From data to knowledge through smart Process Analytical Technologies (PAT) and process systems engineering

3 December 2008 | By

Pharma-Chem and bio-pharma development and production are now being profoundly influenced by the FDA PAT1 initiative with spectroscopic instrumentation being increasingly applied, or at the very least explored in product and process development and for on-line real-time process applications. The issues related to robust spectroscopic data analysis and calibration modelling…

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IFPAC…The first name in PAT…The essential name in PAT

3 December 2008 | By

This premier event is being held January 25-28 at the Baltimore Marriott Waterfront Hotel, located within Baltimore's Inner Harbour. IFPAC is the leading conference in process analysis and technology and this will be the 23rd International Forum for Process Analytical Technology.