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Two-dimensional liquid chromatography (2D-LC) has obtained increasing focus over the past two decades. At LEO Pharma, we continuously evaluate new laboratory techniques with the potential to advance our drug discovery and development. We installed a MHC 2D-LC 18 months ago and have found it valuable in a broad range of…
In this Separations & Purifications In-Depth Focus: Experts from Leo Pharma explain how they use an MHC 2D-LC system in their analytical troubleshooting laboratory and how it can be applied to solve key tasks in the lab. Plus, Dave Elder explains how guidance for mutagenic impurities has necessitated control of…
Opioid overdose in the US and in Europe is on the rise, and the role of prescription-sourced drugs such as oxycodone cannot be underestimated...
European Pharmaceutical Review, Issue 2 of 2016 focused on nanotechnology and stem cell technology to monitor glucose and prevent diabetes, respectively. The aim of this review is to sensitise the technology innovators in this field by providing expert opinions on biomedical products and technologies that have come the closest so…
In this Raman Spectroscopy In-Depth Focus: Subvisible particle identification in protein-based formulations by Raman spectroscopy; Raman spectroscopy as a blood glucose monitoring tool...
In the last issue of European Pharmaceutical Review (vol 22, issue 2), Jeanne Moldenhauer suggested the pharmaceutical industry has moved at a “snail’s pace” in terms of implementing rapid microbiological methods (RMM).
The simplest form of life is composed of single-celled microorganisms which are thought to have appeared around 3.5x109 years ago.1 Interestingly, evidence has shown that chloroplasts and mitochondria were once free-living microorganisms that became incorporated into eukaryotic cells and eventually became energy-producing organelles.1 Biodiversity enables microorganisms to survive in extreme…
Simply put, an orphan drug is indicated for the treatment of a very rare disease. Such diseases are often due to genetic defects and therefore children and newborns are affected to a great extent1.
Perhaps the most significant challenge in all of medicine is the need for more effective treatments for cancer, which causes one of every four deaths in the United States and bears a direct cost to our healthcare system of close to $100bn annually.
Welcome to European Pharmaceutical Review’s Guide to Testing Services, the second in our new series of ‘Guide to …’ supplements. In this edition, five leading testing service suppliers explain how their service offering meets current industry needs...
Subvisible particles in protein-based formulations can have different origins. Particles can be extrinsic (unexpected foreign material), intrinsic (from the production environment or primary packaging), and inherent (from the formulation). It is important that inherent particles (protein agglomerates) are distinguished from the other two types and that the extrinsic and intrinsic…
Classically, isolation of key intermediates and the resultant active pharmaceutical ingredient (API) has formed the basis of clean up and purification strategies within the pharmaceutical industry...
In this Formulation Development & Delivery In-Depth Focus: A report on the use of freeze-drying to develop orally disintegrating tablets; a review of mucosal drug delivery; an interview on drug delivery through the skin; and a profile of three analytical technologies used to develop drug delivery systems...
In this supplement, we've brought together a collection of interesting posters from leading companies in order to celebrate cutting-edge research in the pharmaceutical industry and to share with our readers some of the varied work being carried out by their colleagues...
In Issue #3 2017: In-Depth Focuses covering Raman Spectroscopy, Separations & Purifications, Formulation Development & Delivery; Guide To Testing Services; GMP and mutual recognition; Regulatory Insight; RMMs; Microbiology Series; and much more...
