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Ulcerative colitis (UC)

CHMP meeting highlights – March 2023

3 April 2023 | By Catherine Eckford (European Pharmaceutical Review)

In the European Medicines Agency's March human medicines committee meeting, nine new medicines were recommended, including one for multiple sclerosis.

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First biosimilar to HUMIRA^® available in US

2 February 2023 | By Catherine Eckford (European Pharmaceutical Review)

AMJEVITA™, the first biosimilar to Humira® is now available in the US, based on four years of real-world experience in over 300,000 patients.

Citrate-free HCF of adalimumab biosimilar gets positive opinion - citrate-free high concentration formulation

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Citrate-free HCF of adalimumab biosimilar gets positive opinion

30 January 2023 | By Catherine Eckford (European Pharmaceutical Review)

A positive opinion has been adopted by the CHMP for a citrate-free high concentration formulation of its biosimilar Hyrimoz® (adalimumab).

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Clinical trials authorised for 3D-printed ulcerative colitis drug

22 November 2022 | By Catherine Eckford (European Pharmaceutical Review)

The FDA gives clinical trial clearance to 3D-printed colon-targeted oral drug for ulcerative colitis, to help improve safety of the dosage release.

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JAK inhibitors increase risk of cardiovascular problems and cancer, warns PRAC

1 November 2022 | By Catherine Eckford (European Pharmaceutical Review)

Janus kinase inhibitors used for chronic inflammatory conditions are only safe for certain patients, advises the EMA’s safety committee.

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Biosimilar competition saves US healthcare $21 billion

14 October 2022 | By Catherine Eckford (European Pharmaceutical Review)

The US biosimilars market experienced dramatic growth in 2022, particularly for therapies helping to treat oncological and inflammatory conditions, Amgen suggested in a recent report.

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Robotic capsule could replace injected biologics

13 October 2022 | By Catherine Eckford (European Pharmaceutical Review)

MIT researchers have developed a robotic capsule that tunnels through mucus in the GI tract to deliver large oral protein-based drugs like insulin.

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NICE recommends first oral S1P receptor modulator for ulcerative colitis

7 October 2022 | By Catherine Eckford (European Pharmaceutical Review)

NICE has recommended the drug Zeposia® (ozanimod) for moderate to severe cases of ulcerative colitis.

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Positive top-line results for Etrasimod in treatment of ulcerative colitis

1 April 2022 | By European Pharmaceutical Review

Phase III study results show ulcerative colitis patients treated with etrasimod achieved statistically significant improvements in clinical remission compared to placebo.

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EC approve Zeposia^® to treat ulcerative colitis

26 November 2021 | By Anna Begley (European Pharmaceutical Review)

The European Commission (EC) has granted Zeposia® (ozanimod) a marketing authorisation to treat people with ulcerative colitis.

Woman holding stomach highlighted in red

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Stelara^® shows promise to treat gut diseases in new analyses

28 October 2021 | By Anna Begley (European Pharmaceutical Review)

Two new analyses displayed positive data supporting Stelara for the treatment of Crohn's disease and ulcerative colitis.

3D illustration of the small and large intestines (highlighted in orange) within the human abdomen - idea of inflammatory bowel diseases such as Crohn's disease or Ulcerative Colitis

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Stelara^® “a compelling option” for the treatment of Crohn’s disease

24 May 2021 | By Hannah Balfour (European Pharmaceutical Review)

Janssen has released abstracts for four studies evaluating Stelara® (ustekinumab) in Crohn's disease (CD) and ulcerative colitis (UC).

Close up of a man holding his stomach with the outline of a large intestine drawn on it and glowing in red - idea of gastrointestinal issues like ulcerative colitis

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Upadacitinib meets all endpoints in Phase III ulcerative colitis trial

23 February 2021 | By Hannah Balfour (European Pharmaceutical Review)

In the trial, 74 percent of participants responded to upadacitinib and 33 percent of patients achieved clinical remission.

Slanted grouping of self application syringe pens on seamless yellow background.

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EC approves first high concentration, low-volume adalimumab biosimilar

16 February 2021 | By Hannah Balfour (European Pharmaceutical Review)

YuflymaTM (CT-P17) has been approved for the treatment of thirteen chronic inflammatory diseases, including rheumatoid arthritis, ulcerative colitis and psoriatic arthritis, in Europe.

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First-in-human trial to study remestemcel-L as Crohn’s disease therapy launched

26 October 2020 | By Victoria Rees (European Pharmaceutical Review)

A Phase I clinical trial of remestemcel-L delivered by an endoscope to patients with Crohn’s disease and ulcerative colitis has commenced.

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Ulcerative colitis (UC)