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Thermally-stable TB vaccine developed using new technique
A new process developed by the University of Bath protects a TB antigen and a novel vaccine adjuvant from heat damage.
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Tuberculosis
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Tuberculosis: fighting the disease with a single vial
Vaccinations have begun in a phase I human clinical trial testing a freeze-dried, temperature-stable formulation of an experimental tuberculosis vaccine candidate. Nikki Withers speaks to Dr Daniel Hoft and Christopher Fox about the formulation process and what this means for vaccine development going forward.
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Collaboration to produce new clinical stage TB drug candidates
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded TB Alliance a CETR grant for tuberculosis drug development.
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Freeze-dried TB vaccine candidate enters Phase 1 human clinical trial
A vaccine that does not require a cold chain could be much more easily distributed to communities in need…
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Higher rifampin doses for TB appear more effective with no greater risks
Higher daily doses of rifampin, a cornerstone of tuberculosis treatment, were shown to kill more TB bacteria in sputum cultures without increasing the adverse effects of treatment, according to a recent randomised controlled trial.
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Repurposing cancer drugs may lead to a new approach to treating TB
Promising experimental cancer chemotherapy drugs may help knock out another life-threatening disease: tuberculosis (TB)...
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Cancer drug helps treat tuberculosis by restoring leaky blood vessels
Drug that strengthens blood vessels allows antibiotics to infiltrate tuberculosis granulomas in mice...
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Blood test found to predict onset of TB up to two years in advance
A new blood test has been found to more accurately predict the development of tuberculosis up to two years before its onset in people living with someone with active TB...
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Algorithm proves its worth in preventing spread of infectious diseases
Scientists in California have undertaken studies that have demonstrated the effectiveness of a sophisticated algorithm in preventing the spread of infectious diseases. The application of AI allows authorities to identify the best use of resources and highlight subtle interaction points that might otherwise be missed.
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TB vaccine trial results offer potential for BCG revaccination
Study is the first 'prevention of infection' trial conducted for tuberculosis, the world's leading infectious disease killer...
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New research into old antibiotic unearths potential improved TB drug
A study by the University of Warwick and the Francis Crick Institute has enabled a deeper understanding of the mechanism of action of antibiotic drug, D-cycloserine, which holds promise for future TB treatment.
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Lansoprazole a gastric acid suppressant may target TB
A cheap and widely used drug, used to treat conditions such as heartburn, gastritis and ulcers, could work against the bacteria that cause TB...
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NICE publishes new guideline to better tackle TB
13 January 2016 | By Victoria White
The new guidance combines clinical advice and public health guidance for the first time...
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Otsuka announces efficacy results for delamanid for extensively drug-resistant tuberculosis
16 July 2015 | By Victoria White
Data from a post-hoc subset analysis of Phase IIb clinical trials suggests the potential efficacy of Otsuka’s delamanid for the treatment of XDR-TB...
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Over-the-counter antacid lansoprazole could be an effective anti-tuberculosis drug
7 July 2015 | By Victoria White
Testing thousands of approved drugs, EPFL scientists have found that an over-the-counter antacid, lansoprazole, may be an effective anti-tuberculosis drug...
