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diffuse large B-cell lymphoma (DLBCL)

Non-chemotherapy lymphoma treatment may provide durable remission

19 June 2024 | By Catherine Eckford (European Pharmaceutical Review)

Fifty four percent of evaluable patients with DLBCL attained a substantial tumour reduction with the five-drug regimen, trial data shows.

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NICE recommends injectable bispecific antibody for aggressive blood cancer

1 February 2024 | By Catherine Eckford (European Pharmaceutical Review)

Recommendation of AbbVie’s bispecific antibody for NHS use is based on a Phase I/II trial, which observed a 62 percent overall response rate in diffuse large B-cell lymphoma (DLBCL) patients.

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Long-term findings from CAR NK cell therapy trial revealed

18 January 2024 | By Catherine Eckford (European Pharmaceutical Review)

One-year results from a cancer therapy trial has reported key findings for the selection criteria for allogeneic cord blood donors in CAR NK cell manufacturing.

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Bispecific antibody approved in Europe for DLBCL

11 July 2023 | By Catherine Eckford (European Pharmaceutical Review)

European approval of the bispecific antibody treatment has the potential to change the current standard of care in diffuse large B-cell lymphoma (DLBCL).

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FDA approves off-the-shelf bispecific antibody cancer therapy

16 June 2023 | By Catherine Eckford (European Pharmaceutical Review)

The US Food and Drug Administration (FDA) has approved the first bispecific antibody with a fixed-duration treatment in (R/R) diffuse large B-cell lymphoma (DLBCL).

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European Commission approves CAR T therapy for lymphoma

3 May 2023 | By Catherine Eckford (European Pharmaceutical Review)

CD19-directed CAR T-cell therapy Breyanzi has been approved by the European Commission (EC) based on significant results from a lymphoma Phase III trial.

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Yescarta^® demonstrates promising European manufacturing experience

24 April 2023 | By Catherine Eckford (European Pharmaceutical Review)

In newly published analysis, Kite's CAR T-cell therapy delivered a reduced median European manufacturing turnaround time for diffuse large B-cell lymphoma (DLBCL) patients.

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FDA approves first new B-cell lymphoma treatment in 20 years

20 April 2023 | By Catherine Eckford (European Pharmaceutical Review)

A first-line B-cell lymphoma treatment shown to reduce the risk of disease progression or relapse by 27 percent has been approved by the FDA.

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EMA releases human medicines highlights 2022 report

17 February 2023 | By Catherine Eckford (European Pharmaceutical Review)

Medicines which represented significant progress in their therapeutic areas have been listed in the European Medicines Agency's Human Medicines Highlights 2022 report.

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CD19 CAR-T agents to boost blood cancer market

8 February 2023 | By Catherine Eckford (European Pharmaceutical Review)

GlobalData says CD19 CAR-T agents are expected to treat over 13,000 blood cancer patients annually by 2031, driving sales of Breyanzi and Yescarta.

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First CAR T-cell therapy recommended on NHS

26 January 2023 | By Catherine Eckford (European Pharmaceutical Review)

NICE’s recommendation of Yescarta® means it is the first time patients will be able to access CAR T-cell therapy long-term on the NHS.

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France’s ATU reform: early access remains possible, but not all diseases are equal

6 December 2022 | By Cécile Matthews (CRA), Charlotte Capdevila

When France's ATU reform was implemented, some viewed it as restrictive. Here, Cécile Matthews and Charlotte Capdevila explore the reform’s impact on early access to oncology drugs and products for rare diseases.

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FDA priority review for AbbVie lymphoma bispecific antibody

22 November 2022 | By Catherine Eckford (European Pharmaceutical Review)

The FDA has accepted priority review of epcoritamab for adults with relapsed/refractory large B-cell lymphoma, which could be the first subcutaneous bispecific antibody for large B-cell lymphoma.

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EMA validates AbbVie lymphoma bispecific antibody application

31 October 2022 | By Catherine Eckford (European Pharmaceutical Review)

AbbVie's marketing application for epcoritamab in adults with relapsed/refractory diffuse large B-cell lymphoma has been validated by the European Medicines Agency.

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EC approves CAR T-Cell therapy for B-cell lymphoma

19 October 2022 | By Izzy Wood (European Pharmaceutical Review)

Yescarta approved by EC for the treatment of large B-Cell lypmphoma and high grade B-cell lymphoma.

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diffuse large B-cell lymphoma (DLBCL)