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Vitamin D supplements could ease painful IBS symptoms
Researchers find that vitamin D supplements could help to ease painful Irritable Bowel Syndrome symptoms...
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Nanoparticle vaccine offers universal protection against influenza
Researchers have developed a universal vaccine to combat influenza A viruses that produces long-lasting immunity...
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Combination chemotherapy may significantly improve treatment for glioblastoma
Addition of hydroxyurea to current chemotherapy significantly improved survival in animal models of glioblastoma...
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EC approves first biosimilar Mvasi for the treatment of cancer
The European Commission has granted marketing authorisation for Mvasi for the treatment of certain types of cancer...
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Fosmidomycin-piperaquine combination provides promising malaria treatment
An international research team has conducted successful phase II clinical tests of a new anti-malaria medication...
article
Rational drug design: How far have we come?
From the early use of Hansch parameters and Topliss Trees to today’s computational structure–activity techniques, medicinal chemists have long sought to rationalise drug design to find the quickest and most resource-efficient route to market. But while modern strategies are more reliant on statistical algorithms and vast data libraries, these founding…
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Promacta receives Breakthrough Therapy designation for SAA
The FDA has granted Breakthrough Therapy designation to Promacta for use in combination with standard immunosuppressive therapy for severe aplastic anaemia...
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5-FU cream found to reduce the risk of squamous cell carcinoma
Clinical trial results provide evidence that using the generic skin cream fluorouacil 5 percent for two to four weeks may reduce the risk of SCC...
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Kisqali receives breakthrough therapy designation for advanced breast cancer
Kisqali receives breakthrough therapy designation for initial endocrine-based treatment of pre- or perimenopausal women with HR+/HER2- advanced or metastatic breast cancer...
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Aqueous solubility-enhancing excipient technologies: a review of recent developments
At least some degree of solubility in water is necessary for active ingredients in pharmaceutical products to be effective in vivo. However, as efforts to discover and synthesise new active ingredients are pursued by industrial and academic medicinal chemists, achieving sufficient aqueous solubility can often be a significant limitation to…
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Diabetes drug significantly reverses memory loss in Alzheimer’s disease
A drug developed for diabetes could be used to treat Alzheimer's after scientists discover it significantly reversed memory loss in mice through a triple method of action...
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Non-clinical dose formulation considerations
Designing appropriate non-clinical safety studies requires thoughtful, and sometimes experimental, consideration of the delivery methodology for the therapeutic. The choice of formulation affects drug release and absorption and has a direct impact on the pharmacokinetic profile and associated response of the model system. The formulation should be compatible with the…
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Issue #6 2017 – Digital Version
This issue celebrates European Pharmaceutical Review's 21st birthday through 21 interviews with leading lights from across the pharmaceutical industry...
whitepaper
Application Note: A new crystallinity gauge: Real-time quantification and monitoring of crystallinity in pharmaceuticals
The measurement and quantification of crystallinity in pharmaceuticals is of vital importance, as this has a direct influence on the solubility and stability of the final drug product, affecting both efficacy and expiration...
whitepaper
Whitepaper: Perform conductivity measurements in compliance with USP <645>
“Water is the most widely used substance, raw material, or ingredient in the production, processing and formulation of compendial articles...”
