news
Graphene boosts chemotherapy treatment effect
9 July 2015 | By Victoria White
Researchers have been studying what happens when different chemotherapy drugs come in contact with the silver coating on catheters with surprising results...
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Analytical techniques
news
Over-the-counter antacid lansoprazole could be an effective anti-tuberculosis drug
7 July 2015 | By Victoria White
Testing thousands of approved drugs, EPFL scientists have found that an over-the-counter antacid, lansoprazole, may be an effective anti-tuberculosis drug...
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Issue #3 2015 – Digital edition
In Issue #3 2015: Regulatory Insight, Microfluidics, PCR in-depth focus, Drug Delivery, Content Uniformity, HPLC, Microbiology in-depth focus, NMR, PAT and much more...
article
Revolutionising Raman with the transmission technique
3 July 2015 | By Julien Villaumié and Hilary Jeffreys, Actavis
All regulatory agencies require that manufacturers accurately determine the amount of drug in a medicinal product so that the product can be deemed fit for patients. This forms part of batch release testing performed by Quality Control (QC) laboratories. The drug assay and/or content uniformity of the dosage units is…
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Universal detection in high performance liquid chromatography
3 July 2015 | By David P. Elder, Phil Borman and George Okafo - GlaxoSmithKline
The most commonly used analytical technique for the testing of drug molecules is reversed-phase high performance liquid chromatography (RP-HPLC) with ultraviolet (UV)/visible detection. However, one of the biggest constraints affecting UV/visible detectors is their inability to generate adequate sensitivity for analytes lacking a suitable UV chromophore.
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Fast quantitative 2D NMR for quantifying analytes in complex mixtures
3 July 2015 | By Patrick Giraudeau, University of Nantes
Nuclear magnetic resonance (NMR) spectrometry is a major quantitative tool in pharmaceutical analysis, owing to its extremely high accuracy. However, absolute quantification in complex mixtures is often hampered by spectral overlap which considerably reduces the quantitative performance of NMR.
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PAT Series: Applicability of process analytical tools to bioprocessing trends
3 July 2015 | By Payal Roychoudhury, PhD, formerly AstraZeneca
The past decade has been a period of unparalleled change and development in the fermentation industry. As the nature of this industry evolves, and in particular, with the increasing prominence of the new biopharmaceuticals (therapeutic proteins, diagnostic enzymes and monoclonal antibodies) the need for effective bioprocess monitoring grows in importance1.
whitepaper
Whitepaper: Analysis of a Mammalian cell culture
In this free whitepaper we discuss real-time, in situ bioprocess understanding in accordance with the PAT initiative and comparison of Raman and NIR spectra of cell culture components...
news
Next-generation system redefines performance for GC-MS Applications
Laboratories performing food safety and authenticity, pharmaceutical, metabolomic, anti-doping and other analyses using gas chromatography-mass spectrometry (GC-MS) can now achieve new levels of performance using high-resolution accurate-mass (HRAM) Orbitrap mass spectrometry, bringing the highest level of detection and identification capabilities to GC-MS studies.
news
New Tribrid Mass Spectrometer from Thermo Scientific
New Tribrid Mass Spectrometer with improved sensitivity redefines the limits of protein and small molecule quantitation and characterization...
news
New high purity grade of solvents for UHPLC-MS instrumentation
New, exceptionally pure mobile phase solvents for ultra-high-performance liquid chromatography–mass spectrometry (UHPLC-MS) instruments have been designed to reduce background signal and minimize chromatographic interferences, facilitating accurate, sensitive and rapid trace analysis.
news
Blaze Bioscience announces open enrollment for Phase 1 clinical trial of Tumour Paint BLZ-100 in children with brain cancer
4 June 2015 | By Victoria White
Blaze Bioscience has announced open enrollment for the first clinical study of Tumour Paint BLZ-100 in children with brain cancer...
webinar
Accelerating Pharma R&D using Mass Spectrometry and NMR
14 May 2015 | By Bruker Daltonics
In this recorded webinar three experts from Bruker Daltonics and University of Dundee introduce novel MS and NMR solutions and its applications in pharmaceutical research...
news
New innovations in upstream and downstream bioprocessing on display at Interphex 2015
Thermo Fisher Scientific Inc., the world leader in serving science, is unveiling new bioprocessing technologies to address the evolving needs for enhancing the efficiency and productivity of global biopharmaceutical manufacturers. These advancements include single-use systems, purification, cell culture media, analytical systems, adherent cell culture, customized fluid transfer systems and laboratory…
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Issue #2 2015 – Digital edition
In Issue #2 2015: Outsourcing, Drug pricing reforms, Stem Cells in-depth focus, Microbiology series, Environmental monitoring, LC-MS in-depth focus, Manufacturing solutions, PAT series and much more...
