Analytical techniques

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PAT Series: Predictive monitoring and control approaches in biopharmaceutical manufacturing

3 September 2015 | By Cenk Undey, Tony Wang, Bryan Looze, Yingying Zheng and Myra Coufal - Amgen

Predictive monitoring is a key feature of biopharmaceutical manufacturing; making predictions about the key process end points such as process performance indicators or quality attributes using a process model offers the unique advantages of process improvement and optimisation, and helps give insights into variability.

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Application note: High-throughput Screening of Deubiquitylase enzyme (DUB) activity/specificity and inhibitor screening by MALDI-TOF mass spectrometry

1 September 2015 | By Bruker

In biopharmaceutical laboratories, there is a growing need for high-throughput, yet sensitive methodologies to characterize deubiquitylase enzymes (DUBs) and DUB inhibitors...

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Whitepaper: Current trends in Raman Spectroscopy for Upstream Bioprocess Monitoring and Control

1 September 2015 | By Kaiser Optical Systems

This application note covers some new trends in bioprocess monitoring and control focusing on the increasing use of Kaiser Optical Systems Raman spectrometers as multi-measurement bioprocess sensors to enable quality by design, process optimization, process control and continuous processing...

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Mettler Toledo introduces new high performance Thermal Analysis products for premium results

10 August 2015 | By Mettler Toledo

METTLER TOLEDO is pleased to introduce two new products to the Thermal Analysis Premium portfolio, the DSC3+ and TGA/DSC 3+, for superior results on the most demanding applications...

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Wickham Laboratories announces upcoming webinar on Rapid Methods

7 August 2015 | By Wickham Laboratories Limited

Join us for a discussion on Rapid Screening Techniques, October 1 3PM London/10AM New York...

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World’s first international pharmaceutical seminar on Transmission Raman Spectroscopy

31 July 2015 | By Cobalt Light System

Cobalt is hosting the first ever seminar on the use of Transmission Raman Spectroscopy (TRS) in quantitative pharmaceutical analysis...

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Four-channel HPLC increases clinical throughput capabilities with Class I medical device listing

27 July 2015 | By Thermo Fisher Scientific

Clinical laboratories requiring high-throughput separations for their LC-MS assays now have access to a new four-channel, high-performance liquid chromatography (HPLC) system designed to increase the productivity and efficiency of clinical sample separations, while freeing valuable bench space.

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Increasing Throughput and Sensitivity of LC-MS assays with a focus on MS optimisation and novel LC strategies

13 July 2015 | By Sciex

Simplifying peptide quantification with automated optimisation of MRM transitions and advantages of Micro flow LC to maximise LC-MS performance...

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Basics of calibration and adjustment in Thermal Analysis – Useful tips and hints

13 July 2015 | By METTLER TOLEDO

In this webinar, we discuss the basics of calibration and adjustment in thermal analysis whilst offering some useful tips and hints...

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Graphene boosts chemotherapy treatment effect

9 July 2015 | By Victoria White

Researchers have been studying what happens when different chemotherapy drugs come in contact with the silver coating on catheters with surprising results...

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Over-the-counter antacid lansoprazole could be an effective anti-tuberculosis drug

7 July 2015 | By Victoria White

Testing thousands of approved drugs, EPFL scientists have found that an over-the-counter antacid, lansoprazole, may be an effective anti-tuberculosis drug...

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Issue #3 2015 – Digital edition

3 July 2015 | By European Pharmaceutical Review

In Issue #3 2015: Regulatory Insight, Microfluidics, PCR in-depth focus, Drug Delivery, Content Uniformity, HPLC, Microbiology in-depth focus, NMR, PAT and much more...

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Revolutionising Raman with the transmission technique

3 July 2015 | By Julien Villaumié and Hilary Jeffreys, Actavis

All regulatory agencies require that manufacturers accurately determine the amount of drug in a medicinal product so that the product can be deemed fit for patients. This forms part of batch release testing performed by Quality Control (QC) laboratories. The drug assay and/or content uniformity of the dosage units is…

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Universal detection in high performance liquid chromatography

3 July 2015 | By David P. Elder, Phil Borman and George Okafo - GlaxoSmithKline

The most commonly used analytical technique for the testing of drug molecules is reversed-phase high performance liquid chromatography (RP-HPLC) with ultraviolet (UV)/visible detection. However, one of the biggest constraints affecting UV/visible detectors is their inability to generate adequate sensitivity for analytes lacking a suitable UV chromophore.

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Fast quantitative 2D NMR for quantifying analytes in complex mixtures

3 July 2015 | By Patrick Giraudeau, University of Nantes

Nuclear magnetic resonance (NMR) spectrometry is a major quantitative tool in pharmaceutical analysis, owing to its extremely high accuracy. However, absolute quantification in complex mixtures is often hampered by spectral overlap which considerably reduces the quantitative performance of NMR.