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Treating malaria using artemisinin-based combination therapy (ACT)
The artemisinin-based combination therapy (ACT), pyronaridine-artesunate, has been shown to be as effective in treating malaria as other drugs...
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Analytical techniques
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The greener alternative for drug production
Researchers have developed a method using environmentally-friendly water and stable bonding between carbon and manganese instead of highly reactive metals...
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Clinically relevant dissolution specifications: selection and assessment
Setting specifications for new oral products can be challenging. Too lenient, and there is a risk of passing batches of inadequate quality; too stringent, and there is a risk of rejecting acceptable batches.
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Hormone therapy could be key in treating knee osteoarthritis
A study has found that the prevalence of knee osteoarthritis was significantly lower in participants using hormone therapy than those not taking hormones...
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Pharmaceutical corridor between Hong Kong and Brussels opens
The pharma corridor between Hong Kong and Brussels Airport assures handling quality for temperature-sensitive pharmaceuticals.
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Prescribed opioids raise risk of pneumonia
A study has found that opioids, including morphine, codeine and fentanyl increase the likelihood of patients being affected by pneumonia...
whitepaper
Application Note: Quantitation of intact therapeutic protein in plasma matrix by LC/MS
A complete workflow to quantify intact therapeutic proteins in plasma matrix has been developed, covering three critical components in preclinical sample analysis: target protein enrichment/purification, LC/MS data acquisition and quantitative data analysis.
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Ustekinumab could be approved to treat ulcerative colitis
Ustekinumab has been submitted to be the first interleukin (IL)-12/23 inhibitor licensed for the treatment of ulcerative colitis...
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ADHD drugs unlikely to cause cardiac damage in children
The results of a long-term study on the use of ADHD medication has advised that they are unlikely to result in heart damage, or cardiac difficulties...
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Deloitte finds Pharma returns on R&D reach new low
Deloitte has found a sharp decline in the returns on investment from top pharmaceutical companies, with returns at almost half of what they were in 2010...
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Clinical trial to develop breath test for cancer launched
A clinical trial to analyse breath for volatile organic compounds to detect different types of cancer has been launched by Cancer Research UK...
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Canagliflozin may not be associated with fracture risk in diabetes patients
A study has found that when compared with other drugs, canagliflozin may not be associated with fractures in patients with diabetes...
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Correcting minority underrepresentation in MS clinical trials
Minority underrepresentation in clinical trials for drugs to treat MS has led to doctors being unable to make informed decisions when prescribing...
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Tailor-made excipients, developed the Kolb way
Standard excipients can be sourced from various suppliers, but what if you need to customise an excipient to suit your needs?
article
Expert View: Beyond API monitoring: in‑line Raman spectroscopy for bioprocess monitoring and control
The FDA’s Quality by Design (QbD) initiative brought a paradigm shift to pharmaceutical manufacturing and leading manufacturers have realised improved processes after adopting QbD. Raman spectroscopy is an established Process Analytical Technology (PAT), enabling QbD and continuous approaches to pharmaceutical manufacturing.1
