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This presentation will provide method development guidance for the extraction and quantification of analytes using headspace SPME.
The prerequisite of any highly sensitive analysis via HPLC-MS (high performance liquid chromatography coupled to mass spectrometry) is the use of ultrapure solvents and reagents and careful handling of all associated materials, consumables, and systems.
Combining the world's fastest proteomics instrument with over 25 years of MALDI experience.
The timsTOF Pro with diaPASEF enables deeper proteome coverage in a single 4D shotgun proteomics experiment, with highly reproducible qualitative and quantitative results - making it a near-ideal mass analyzer for proteomics.
Purification of a drug from host cell protein contaminants can be challenging, with low-level contamination often remaining after purification. Vanda Dolabela de Magalhães shares discussions on the subject from six Brazilian companies working in the biotech field.
The efficacy, safety and pharmacokinetic properties of a protein therapeutic substantially depend on the molecule having the right structure. This article reviews current methods used for obtaining higher order structure information of biotherapeutics.
This seminar describes different membrane characteristics and provides guidance in selecting the right filtration devices for sample preparation following in vitro dissolution.
Many researchers are keen to find analytical solutions that generate the chemical fingerprint of a sample at the molecular and cellular level. Overcoming these problems is made possible by label-free techniques such as Raman, SPRi or particle size analysis. This brief overview will identify the benefits of Raman spectroscopy.
When it comes to microbial contamination testing, false results can waste valuable time.
Microbial risk in pharmaceutical process is not limited to living microorganisms and intact microbial cells.
High-resolution measurements of particles are of great interest in many fields of application. Combining confocal Raman microscopy with particle analysis tools makes it possible to find, classify and identify particles almost entirely automatically.
ADVANCES in biotherapeutics are generating an increasing range of complex molecules that present unique and often complex purification challenges.
The practice of bottom-up proteomics relies to a large extent on the separation performance that can be achieved with state-of-the art nano LC-MS/MS equipment.
To ensure that USP/EP standards are met, TOC of highly purified water can be determined by internal purification-process monitoring.
Antibody-drug conjugates (ADC) represent a rapidly emerging class of biotherapeutic molecules, which harness the specificity of monoclonal antibodies (mAb) to selectively deliver highly potent cytotoxic drugs. Like all biotherapeutics they require significant analytical characterization.
