Lars Decker Nielsen

Scientists in lab performing two dimensional liquid chromatography

Two-dimensional liquid chromatography (2D-LC) with multiple heart-cutting

23 May 2018 | By Lars Decker Nielsen, Naja Wessel Jacobsen

Two-dimensional liquid chromatography (2D-LC) has obtained increasing focus over the past two decades. At LEO Pharma, we continuously evaluate new laboratory techniques with the potential to advance our drug discovery and development. We installed a MHC 2D-LC 18 months ago and have found it valuable in a broad range of…

reference

Jacobsen NW, Nielsen LD. Two-dimensional liquid chromatography (2D-LC) with multiple heart-cutting in a troubleshooting laboratory. European Pharmaceutical Review. 2017;3:60-63

12 July 2017 | By Lars Decker Nielsen, Naja Wessel Jacobsen

References Stoll DR, Li X, Wang X, Carr PW, Porter SEG, Rutan SC. Fast, comprehensive two-dimensional liquid chromatography, J Chromatogr A. 2007;1168(1–2):3-43. doi:10.1016/j.chroma.2007.08.054. Pursch M, Buckenmaier S. Loop-based multiple heart-cutting two-dimensional liquid chromatography for target analysis in complex matrices. Anal Chem. 2015;87(10):5310-7. doi: 10.1021/acs.analchem.5b00492. Chen M, Wang L, Dong…

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Lars Decker Nielsen

Two-dimensional liquid chromatography (2D-LC) with multiple heart-cutting

Jacobsen NW, Nielsen LD. Two-dimensional liquid chromatography (2D-LC) with multiple heart-cutting in a troubleshooting laboratory. European Pharmaceutical Review. 2017;3:60-63