Heiko A. Schiffter (University of Oxford)

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The determination of structural changes of biopharmaceuticals during Freeze-Drying using Fourier Transform Infrared Spectroscopyb

20 March 2009 | By Heiko A. Schiffter (University of Oxford), Sebastian Vonhoff (University of Erlangen-Nuremberg)

Peptides and proteins are powerful active therapeutic ingredients used in a wide variety of serious conditions and illnesses such as diabetes, arthritis or cancer. The application of these so-called biopharmaceuticals has been rapidly increasing since the middle of the 1990s, facilitated by improvements in modern recombinant DNA technology and biotechnological…

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Spray-freeze-drying in the manufacture of pharmaceuticals

23 May 2007 | By Heiko A. Schiffter (University of Oxford)

Over the last decade, the development of new drug delivery methods and devices for dry powder inhalation1, needle-free intradermal powder injection2 or sustained parenteral drug delivery3 has led to an increasing demand for powder formulations incorporating an active pharmaceutical ingredient (API)4,5.