Bernardo Perez-Ramirez (Sanofi)

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Thermodynamic probes of cold instability: application to therapeutic proteins

18 November 2019 | By Bernardo Perez-Ramirez (Sanofi), Robert Simler (Amgen)

Developing a stable therapeutic protein formulation requires an intimate knowledge of the protein and its physical and chemical properties. In this article, Bernardo Perez-Ramirez and Robert Simler discuss the thermodynamic consequences that low temperature can have on the aggregation tendencies of a protein.

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Approaches in subcutaneous delivery of monoclonal antibodies

24 August 2016 | By Bernardo Perez-Ramirez (Sanofi), Claus Geiger (Sanofi), Tanya Mezhebovsky (Sanofi), Till Bussemer (Sanofi)

Currently, subcutaneous delivery of therapeutic proteins is a fast-growing field, especially for such established modalities as monoclonal antibodies, which require large quantities of drug to be administrated. Different approaches, including high protein concentration, speciality formulations and drug delivery matrices, as well as devices enabling a more rapid administration of larger…