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Figure 1

Turn back the clock and be healed Induced pluripotent stem cells and their future impact on drug discovery and regenerative medicine

9 May 2010 | By Paul D. Andrews, Drug Discovery Unit, College of Life Sciences, University of Dundee

They are only four years old and are getting everyone very excited; they were Science Magazine’s ‘Breakthrough of the Year 2008’ and Nature’s ‘Method of the Year 2009.’ Their discoverer, Shinya Yamanaka, shared the Lasker Award last year and is no doubt touted for a future Nobel Prize. ‘They’ are…

Digital polymerase chain reaction; new diagnostic opportunities

22 February 2010 | By

LGC is an international science-based company located in South West London. A progressive and innovative enterprise, LGC operates in socially responsible fields underpinning the health, safety and security of the public, and regulation and enforcement for UK government departments and blue chip clients. Our products and services enable our customers…

DNA sequencing
DNA sequencing

Applying statistical inference in genomics with evidence based pathways: Towards elucidating new functional correlations of biomarkers

22 February 2010 | By Peter Ghazal, Professor of Molecular Genetics and Biomedicine, University of Edinburgh and Head of Division of Pathway Medicine and Associate Director of Centre for Systems Biology, Edinburgh, Al Ivens, Head of Data Analysis, Fios Genomics Ltd and Thorsten Forster, Statistical Bioinformatician, Division of Pathway Medicine, University of Edinburgh

In conventional pharmacogenomic studies, genetic polymorphisms (including single nucleotide and copy number variations) are elucidated from case-control distribution of individuals usually representing ethnicity, severity of disease, and positive or negative response to treatment. However, the interpretation of a single genetic marker in this context is complicated, as the same marker…

The changing landscape of automation in pre-clinical drug discovery

22 February 2010 | By

Over the past decade we have seen a significant realignment of activities associated with drug discovery and this will continue for a multitude of reasons. Within the pharmaceutical industry we have seen significant changes e.g. a decrease in the numbers of drugs that are being approved by the regulatory authorities…

2009: A landmark year for stem cells

22 February 2010 | By

It would be fair to say that these past 12 months have been a watershed year for stem cell science. In years to come we may look back on 2009 and recognise it as the year in which nascent areas of science, medicine and technology came together to slowly nudge…

Professor Conan Fee, University of Canterbury, New Zealand
Professor Conan Fee, University of Canterbury, New Zealand

Protein PEGylation: An overview of chemistry and process considerations

22 February 2010 | By ,

Innovative drug delivery technologies are key components of drug development, with commercial and intellectual values. PEGylation is an excellent example of a delivery system that has scientific and multi-billion dollar commercial importance due to the remarkable improvement in the circulatory half lives of therapeutics, especially for proteins and peptides but…

Microbiological quality for non-sterile drug product for the 21st century

22 February 2010 | By

For decades microbiological quality has remain dormant while the pharmaceutical industry has continued to evolve. Compendial methods and limits, while now generally harmonised throughout the world, still reflect the same methods utilised 100 years ago. Although there is more clarification around the number and types of organisms permitted in products…

Contributing to the Sustainability of the UK Chemicals and Pharmaceuticals Industries

22 February 2010 | By

The Centre for Process Analytics and Control Technology (CPACT) is a unique industry-driven multi-disciplinary research and development club that was formed in 1997 by the Departments of Pure and Applied Chemistry at the University of Strathclyde, the Department of Chemical and Process Engineering at the University of Newcastle and the…

Pittcon Conference and Expo 2010

22 February 2010 | By

Pittcon 2010 will again offer the latest advances in laboratory instrumentation, supplies and services; comprehensive solutions for research problems; new methodologies and techniques for improved productivity; and a wide range of educational opportunities.

Society of Toxicology 2010

22 February 2010 | By

Salt Lake City, Utah, is the host-city for the Society of Toxicology's 49th Annual Meeting. Scientific Sessions will be held at the Salt Palace Convention Centre during the week of 7-11 March 2010.

Analytica 2010

22 February 2010 | By

For the 22nd time, Analytica will bring international experts from the analysis, laboratory-technology and biotechnology sectors together at a single location.

Cancer-secreted microRNAs: Travelers, Messengers, and Blood-borne Biomarkers

22 February 2010 | By

Since the first discovery of microRNA (miRNA) from C. elegans in 19931 studies of this new class of regulatory small RNA have grown rapidly and entered a new era, where they now serve as potential biomarkers and therapeutic targets in human diseases, such as cancers. Recent studies indicating that miRNAs…