The development and regulatory approval of the first autologous CAR T-cell therapies is a huge advance for modern medicine and has been greeted with justifiable excitement. But applications of this technology are still limited, and given the time and cost constraints, more must be done to broaden access to this treatment. Current limitations of CAR-T therapies could potentially be overcome through new advances in the production of T-cell progenitors, suggests Dr Olivier Negre, Chief Scientific Officer of Smart Immune.