Article: Tips & tricks: sensitivity gains in LC-MS
Posted: 2 July 2019 | Merck | No comments yet
The prerequisite of any highly sensitive analysis via HPLC-MS (high performance liquid chromatography coupled to mass spectrometry) is the use of ultrapure solvents and reagents and careful handling of all associated materials, consumables, and systems.
Introduction
This prevents any contamination throughout the entire sample handling process from preparation to MS detection, and improves sensitivity.
In the following sections, various measures and options for maximized LC-MS sensitivity and low limit of detection (LOD) are shown. Each and every tip avoids contaminations causing signal suppression, adduct formation, elevated background noise and increased spectrum complexity.
Please read and download the full Article below:
Related content from this organisation
- MSD set to acquire novel antibody for B-cell malignancies
- Novel immunotherapy combination approved for endometrial cancer
- Innovating small molecule injectables: market forecast to 2033
- Ophthalmology acquisition to advance tri-specific antibody
- Antibody-immunotherapy treatment shows benefit in serious endometrial cancer