New high purity grade of solvents for UHPLC-MS instrumentation

Fisher Chemical Optima UHPLC-MS solvents are high-quality, ultra-pure and designed to address the trace analysis needs of chromatographers performing state-of-the-art UHPLC. These new solvents are qualified for use with UHPLC/MS instrumentation, such as the Thermo Scientific Vanquish system.

The Optima UHPLC-MS solvents will be exhibited for the first time at the 63^rd Annual American Society for Mass Spectrometry Conference, Booth 140 and at the Landmark Suite at the Renaissance Hotel in St. Louis.

UHPLC-MS is becoming the preferred technique to LC-MS in analytical laboratories, as it enables users to perform separations substantially faster, due to the innovative sub-2 micron columns. Submicron filtration also reduces the clogging of instruments, columns and check valves. A typical LC-MS gradient run can take up to 60 minutes, whereas UHPLC-MS can reduce this to just five minutes, while yielding a similar resolution without compromising flow rates.

Optima UHPLC-MS solvents are ideal for detecting trace amounts of analyte by MS/MS using either gradient or direct-flow analysis without baseline interference. Notably, Optima UHPLC-MS solvents provide a very low mass/noise level in both positive- and negative-mode ionization, minimal metal ion content and a low UHPLC-UV response using photo diode array detection.

“The quality of these high-purity solvents is linked directly to the sensitivity of high-end mass spectrometers, where parts-per-trillion levels of analyte can be detected by the signature product ion peaks, “ said Subhra Bhattacharya, senior product development scientist at Thermo Fisher Scientific. “The low signal–to-noise ratio achieved with the Optima UHPLC-MS solvents highlights the ultrahigh purity, resulting in minimal background interference.”

More information on the Fisher Chemical Optima UHPLC-MS solvents can be found by visiting www.fishersci.com/fisherchemical