Multiple Bristol-Myers Squibb oncology compounds to be featured in oral presentations at 56th Annual American Society for Hematology (ASH) meeting

Bristol-Myers Squibb Company (NYSE:BMY) today announced that study results on investigational agents Opdivo (nivolumab), a PD-1 immune checkpoint inhibitor, elotuzumab, an antibody targeted against Signaling Lymphocyte Activation Molecule (SLAMF7), ulocuplumab, an anti-CXCR4 antibody, and Sprycel (dasatinib), will be featured in oral presentations at the 56th annual meeting of the American Society for Hematology (ASH) in San Francisco from December 6-9, 2014. Data will be presented in multiple hematologic malignancies, including Hodgkin lymphoma (HL), non-Hodgkin lymphoma, multiple myeloma, chronic-phase chronic myeloid leukemia (CP-CML), acute myeloid leukemia (AML) and T-Cell acute lymphoblastic leukemia. In May 2014, the U.S. Food and Drug Administration (FDA) granted Opdivo its first Breakthrough Therapy Designation for the treatment of patients with HL after failure of autologous stem cell transplant and brentuximab.

“The breadth of data we are presenting at ASH this year, including data on ulocupumab and findings from our immuno-oncology development programs for Opdivo and elotuzumab, underscores our commitment to research and development in hematology and to improving outcomes for patients across a range of blood cancers,” said Michael Giordano, senior vice president, Head of Development, Oncology, Bristol-Myers Squibb.

Opdivo (nivolumab) Oral Presentations in HL and Lymphoid Malignancies

Data on Opdivo, an investigational PD-1 immune checkpoint inhibitor, will be presented during two oral presentations on Monday, December 8. At 7:00 a.m. PST, preliminary efficacy, safety and biomarker results will be presented from the relapsed or refractory HL cohort of CheckMate – 039, a Phase 1 dose escalation study of patients with relapsed or refractory hematologic malignancies (Abstract #289). At 7:30 a.m. PST, additional results from CheckMate-039 will be presented, including patients with relapsed or refractory non-Hodgkin lymphoma (Abstract#291).

Elotuzumab Oral Presentation in Multiple Myeloma

Final results from the Phase 1b/2 study of elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed or refractory multiple myeloma will be presented in an oral session on Monday, December 8 at 7:15 a.m. PST (Abstract #302).

In May 2014, the FDA granted elotuzumab Breakthrough Therapy Designation for use in combination with one of the commonly used chemotherapy treatments for multiple myeloma (lenalidomide, used in combination with dexamethasone) in patients who have received one or more prior treatments.

Sprycel (dasatinib) Oral Presentations in CP-CML

Results from two Sprycel studies will be highlighted in oral presentations, including five-year data from the Phase 3 trial, DASISION, comparing Sprycel to Gleevec^{® *}(imatinib mesylate) in newly diagnosed CP-CML patients on Sunday, December 7 at 4:45 p.m. PST (Abstract #152) and seven-year data from a Phase 3 study of patients with Gleevec-resistant or intolerant CP-CML on Monday, December 8 at 3:30 p.m. PST (Abstract #520).

^* Gleevec is a registered trademark of Novartis AG

Additional Data Presentations

Results from a Phase 1 study in relapsed/refractory AML, including safety, tolerability and clinical activity of the investigational anti-CXCR4 antibody ulocuplumab will be presented for the first time during an oral presentation on Monday, December 8 at 10:45 a.m. PST (Abstract #386). Additionally, results from a Phase 1 study of the safety and activity of BMS-906024, a notch inhibitor, in patients with relapsed T-Cell acute lymphoblastic leukemia, will be presented during a poster session on Saturday, December 6 between 5:30 and 7:30 p.m. PST (Abstract # 968).

Full session details of the 2014 Annual Meeting can be accessed on the ASH website: http://www.bloodjournal.org/ash-annual-meeting-abstracts?sso-checked=true